通冠汤对冠心病患者血清VEGF与NO的影响

目的探讨冠状动脉粥样硬化性心脏病(CHD)患者血清血管内皮生长因子(VEGF)及一氧化氮(NO)的含量变化。方法选择40例CHD患者,随机分为中药治疗组与西药对照组。中药组用通冠汤治疗,西药组常规给予消心痛和阿司匹林口服,检测2组患者治疗前后血清VEGF和NO的含量。同时选择16例健康体检者作为健康对照。结果CHD患者血清VEGF含量较健康对照组明显增高,血清NO含量明显低于健康对照者(P<0.01);随着心绞痛程度的加重,血清VEGF含量不断升高,NO含量不断下降;中药治疗组治疗后血清VEGF含量较治疗前明显升高(P<0.01),而西药对照组治疗前后血清VEGF含量无明显变化;治疗后中药治疗组和西药对照组血清NO均较治疗前明显上升,差异非常显著(P<0.01),但仍低于健康对照者;中药治疗组与健康对照者比较差异无显著性,西药对照组与健康对照者比较差异非常显著(P<0.01)。结论中药治疗组经治疗后血清VEGF与NO含量均较治疗前明显升高,推测中药可能有促进血管生成的作用。通冠汤治疗CHD疗效优于西药常规治疗。

Effects of Tongguantang on Serum VEGF and NO in Patients of Coronary Heart Disease

Objective To study the changes of serum levels of vascular endothelial growth factor (VEGF) and nitric oxide (NO) in patients of coronary heart disease (CHD). Methods 40 cases with CHD were divided into TCDT group and control group randomly. The control group was treated by regular western medicine of Isosorbide Dinitrate and ASA,while the TCDT group was treated by Tongguantang (TGT). The content of VEGF and NO in serum of the two groups was determined. 16 healthy subjects served as normal group. Results The serum VEGF level of CHD patients was higher while NO level was lower than those of normal subjects (P<0.01). With the degree of angina pectoris getting worse,the serum level of VEGF rose and NO descended. The level of serum VEGF in TCDT group was higher after treatment than pretreatment (P <0.01),and there was no much change in control group before and after treatment. Compared with pretreatment,the level of serum NO in TCDT group and control group rose significantly after treatment (P <0.01),but was lower than normal group. There was not remarkable difference in the level of serum NO between TCDT group and normal group (P>0.05),while control group was still lower than normal group (P <0.01). Conclusion The levels of serum VEGF and NO in TCDT group were higher after treatment than pretreatment,from which we can make a speculation that TGT may have the function of angiogenesis. TGT was more effective than western routine treatment.