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Epoxyalkanoyls as novel ACE inhibitors |
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| Authors: | Hea-Young P Choo Hea-Ran Yoon Hwha-Soon Park Dong-Hyun Kim Jongsei Park Dong H Kim |
| Institution: | 1. School of Pharmacy, Ewha Womans University, 120-740, Seoul, Korea 2. Doping Control Center, Korea Institute of Science & Technology, 130-650, Seoul, Korea 3. Department of Chemistry, Pohang University of Science & Technology, 790-784, Pohang, Korea |
| Abstract: | The epoxyalkanoyl derivatives were designed and synthesized as ACE inhibitors. Coupling of unsaturated carboxylic acids with amino acids and following epoxidation with dimethyldioxirane gave the epoxyalkanoyls with high yield. The inhibitory activity of synthesized compounds on angiotensin converting enzyme was IC50 values of 0.06≈5.5 μM. |
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