高血压患者血压节律与靶器官损害的相关性研究

目的 探讨高血压患者血压节律变化与心、脑、肾等靶器官损害的相关性。方法 应用无创性血压监测仪对84例高血压患者进行24小时动态血压监测,对比血压节律正常(勺型组)和异常(非勺型组)患者心、脑、肾靶器官损害程度。结果 非勺型组24小时平均收缩压和舒张压、白昼平均舒张压、夜间平均收缩压和舒张压、收缩压及舒张压负荷值较勺型组升高(P<0.01);左心室重量和重量指数显著增加(P<0.05,0.01),24小时平均动脉压与左心室重量指数呈显著相关性r=0.55,P<0.01;尿微量白蛋白阳性率明显增高(P<0.05);脑梗死发生率明显增加(P<0.05);组间在偶测平均收缩压和舒张压、白昼平均收缩压均无显著性差异(P>0.05)。结论 血压昼夜节律异常较节律正常的高血压患者有更显著的靶器官损害。

Study of relationship between circadian variation of blood pressure and target organ demage in hypertension

Objective To explore the relationship between circadian variation of blood pressure(BP)and target-organ-damage (TOD) in hypertension. Methods 84 cases of hypertension were monitored by noninvasive ambulant blood pressure monitoring (ABPM) for 24 hours. Degree of TOD (heart, brain and kidneys) was compared between normality circadian variation of BP (dipper type) and abnormality circadian variation of BP (non-dipper type). Results In non-dippers, mean systolic pressure and diastolic pressure in 24 hours, mean diastolic pressure during daytime, mean systolic and diastolic pressure during nighttime and loading value were higher than those in dippers (P0. 05). Conclusion Target-Organ-Damage in dippers occurs more often than in non-dippers.