Matrix metalloproteinase genes in Xenopus development. |
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| Authors: | Michael Harrison Muhammad Abu-Elmagd Timothy Grocott Clara Yates Jelena Gavrilovic Grant N Wheeler |
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| Institution: | School of Biological Sciences, University of East Anglia, Norwich, United Kingsom. |
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| Abstract: | Matrix metalloproteinases (MMPs) are a large family of proteins in vertebrates, consisting of over 24 genes in humans, only a few of which have been identified in Xenopus. Three genes coding for MMPs in Xenopus have been identified and their expression studied during development. The membrane-bound XMMP-14 and -15 (XMT1-MMP and XMT2-MMP) both showed restricted expression patterns, the former principally localising to cranial neural crest tissues and the latter to the epidermis of the embryo. XMMP-7 codes for an MMP that lacks the hemopexin-like domain. It is expressed exclusively in macrophages or other myeloid cell types from early in development. |
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