| ALOX5AP与卒中 |
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| 引用本文： | 梁庆成,高强.ALOX5AP与卒中[J].国际脑血管病杂志,2006,14(5):388-389. |
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| 作者姓名： | 梁庆成 高强 |
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| 作者单位： | 150086,哈尔滨医科大学附属第二医院神经内科;150086,哈尔滨医科大学附属第二医院神经内科 |
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| 摘 要： | ALOX5AP位于染色体13q12-13,编码5-脂氧合酶激活蛋白(FLAP)。FLAP在调节白细胞三烯的形成中起关键作用。研究表明,携带此基因的人群患卒中的风险增高2倍。因此,ALOX5AP在卒中的发病机制中起着重要作用。
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| 关 键 词： | 5-脂氧合酶激活蛋白 卒中 基因 |
| 收稿时间： | 2005-12-05 |
| 修稿时间： | 2005年12月5日 |
Arachidonate 5-Lipoxygenase-Activating Protein and Storke |
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| Qing-Cheng Liang,Qiang Gao.Arachidonate 5-Lipoxygenase-Activating Protein and Storke[J].International Journal of Cerebrovascular Diseases,2006,14(5):388-389. |
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| Authors: | Qing-Cheng Liang Qiang Gao |
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| Institution: | Department of Neurology, the Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China |
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| Abstract: | 5-lipoxygenase-activating protein Gene (ALOX5AP) on chromosome 13q12-13 encodes 5-lipoxygenase-activating protein (FLAP). The latter plays a key role in regulating the synthesis of leukotriene. Studies have suggested that the subjects who carry this gene may increase stroke risk by two times. Therefore, ALOX5AP plays an important role in the pathogenesis of stroke. |
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| Keywords: | 5-lipoxygenase-activating protein Stroke gene |
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