卡托普利对动脉粥样硬化兔心脏再灌注性心律失常的影响

目的探讨卡托普利对动脉粥样硬化兔在体心脏再灌注性心律失常的影响。方法32只新西兰大白兔随机分为对照组、胆固醇组及卡托普利加胆固醇组。分别测定不同实验阶段的血浆内皮素(ET)浓度,丙二醛(MDA)含量及一氧化氮(NO)浓度。记录在体心脏再灌注后30 m in内室性早搏(VES)出现次数及平均室性心动过速(VT)持续时间。结果⑴胆固醇组与卡托普利加胆固醇组比较,胆固醇组内皮素浓度、丙二醛含量显著性增高,一氧化氮浓度显著性降低;⑵卡托普利加胆固醇组心脏再灌注后室性早搏次数及平均室性心动过速持续时间显著少于胆固醇组。结论卡托普利可减轻动脉粥样硬化兔心脏再灌注性心律失常的发生。

Effects of captopril on reperfusion arrhythmias in the atherosclerotic rabbits

Objective To investigate the effects of captopril on reperfusion arrhythmias in atherosclerotic rabbits.Methods A total of 32 New Zealand white rabbits were randomly divided into the control group,cholesterol food group(CF group) and captopril plus cholesterol food group(Cap group).The levels of endothelin(ET),malonaldehyde(MDA) and the content of nitric oxide(NO) were measured in different stage.The duration of ventricular tachycardia and the incidence of ventricular premature beats in 30 minutes after reperfusion were detected.Results The levels of ET and MDA were significantly decreased and the content of NO were significantly increased in the Cap group compared with that of the CF group.The average duration of ventricular tachycardia and the incidence of ventricular premature beats in 30 minutes after reperfusion were significantly reduced in the Cap group compared with the CF group.Conclusion The incidence of arrhythmias induced by the ischemia reperfusion injury may be decreased with the treatment of captopril in the atherosclerotic rabbits.