Transfollicular enhancement of methyl myristate loaded in cationic niosomes incorporated in hair lotion |
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| Authors: | Jiradej Manosroi Charinya Chankhampan Puxvadee Chaikul Worapaka Manosroi |
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| Affiliation: | 1. Department of Pharmaceutical Science, Faculty of Pharmacy, Chiang Mai University, Chiang Mai, Thailand;2. Manose Health and Beauty Research Centre, Muang, Chiang Mai, Thailand;3. Cosmetic Technology Department, Faculty of Science and Technology, North-Chiang Mai University, Chiang Mai, Thailand;4. Research Administration Centre, Chiang Mai University, Chiang Mai, Thailand;5. Manose Health and Beauty Research Centre, Muang, Chiang Mai, Thailand;6. School of Cosmetic Science, Mae Fah Luang University, Chiang Rai, Thailand;7. Department of Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand |
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| Abstract: | Hair lotion containing methyl myristate loaded in cationic niosomes (HL-MMnio) composed of Brij72/cholesterol/DDAB at 7:3:0.65 molar ratio was developed. The remaining percentages of MM loaded in cationic niosomes in hair lotion were higher than free MM in hair lotion of about 1.2 times. The cumulative amounts in porcine skin and the receiver compartment of MM loaded in cationic niosomes incorporated in hair lotion were higher than those of free MM in hair lotion of 1.45 and 1.32 times, respectively. HL-MMnio showed very slightly irritation on rabbit skin, which was disappeared after 4 d. For melanogenesis induction in C57BL/6 mice with aged-induced grey body coat hairs, the highest pigmentation scores of HL-MMnio applied on the dorsal area were observed after 21 days, while hair lotion containing the free MM indicated after 35 days. This study has suggested that HL-MMnio was the high potential formulation for canities treatment. |
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| Keywords: | Cationic niosomes methyl myristate melanogenesis transfollicular canities treatment |
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