Resveratrol solid lipid microparticles as dry powder formulation for nasal delivery,characterization and in vitro deposition study |
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| Authors: | Isabella Martignoni Valentina Trotta Wing-Hin Lee Ching-Yee Loo Michele Pozzoli Paul M Young |
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| Institution: | 1. Department of Chemical and Pharmaceutical Sciences, University of Ferrara, Ferrara, Italy;2. Respiratory Technology, Woolcock Institute of Medical Research and Discipline of Pharmacology, Sydney Medical School, The University of Sydney, NSW, Australia;3. Graduate School of Health-Pharmacy, University of Technology Sydney, NSW, Australia |
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| Abstract: | This study focuses on development and in vitro characterisation of a nasal delivery system based on uncoated or chitosan-coated solid lipid microparticles (SLMs) containing resveratrol, a natural anti-inflammatory molecule, as an effective alternative to the conventional steroidal drugs. The physico-chemical characteristics of the SLMs loaded with resveratrol were evaluated in terms of morphology, size, thermal behaviour and moisture sorption. The SLMs appeared as aggregates larger than 20?μm. In vitro nasal deposition was evaluated using a USP specification Apparatus E 7-stage cascade impactor equipped with a standard or a modified nasal deposition apparatus. More than 95% of resveratrol was recovered onto the nasal deposition chamber and stage 1 of impactor, suggesting that the SLMs mostly deposited in the nasal cavity. Additionally, the SLMs were not toxic on RPMI 2650 nasal cell line up to a concentration of approximately 40?μM of resveratrol. |
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| Keywords: | Nasal drug delivery solid lipid microparticles chitosan in vitro models |
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