| 经冠状窦逆灌注卡托普利对犬缺血心肌的保护作用 |
| |
| 引用本文： | 曾小林,张钧华,唐朝枢,唐承君. 经冠状窦逆灌注卡托普利对犬缺血心肌的保护作用[J]. 中南大学学报(医学版), 1997, 0(1) |
| |
| 作者姓名： | 曾小林 张钧华 唐朝枢 唐承君 |
| |
| 作者单位： | 湖南医科大学湘雅医院内科，北京医科大学第一医院内科，中国医学科学院阜外医院外科 |
| |
| 摘 要： | 在犬急性心肌梗死（ＡＭＩ）模型上观察经冠状窦逆灌注卡托普利对缺血心肌的保护作用。结果发现，逆灌注组比静脉组缩小的ＡＭＩ面积更大，并降低了冠状窦血浆内皮素及丙二醛的含量。提示冠状动脉阻塞时，经冠状窦逆灌注卡托普利能充分到达ＡＭＩ区，通过抑制此区局部内皮素的释放及在此区局部抗氧自由基作用，从而更有效地保护缺血心肌。
|
| 关 键 词： | 心肌梗死；卡托普利；内皮素；自由基类；灌注法；狗 |
THE PROTECTIVE EFFECT OF CAPTOPRIL ON THE ISCHEMIC MYOCARDIUM IN DOGS THROUGH CORONARY SINUS RETROPERFUSION |
| |
| Zeng Xiaolin. THE PROTECTIVE EFFECT OF CAPTOPRIL ON THE ISCHEMIC MYOCARDIUM IN DOGS THROUGH CORONARY SINUS RETROPERFUSION[J]. Journal of Central South University. Medical sciences, 1997, 0(1) |
| |
| Authors: | Zeng Xiaolin |
| |
| Abstract: | The protective effect of coronary sinus retroperfusion of Captopril on the ischemic myocardium was observed in dogs with acute myocardial infarction(AMI). The results showed that the infarction size and the level of coronary sinus plasma endothelin(ET) and manodialdenyde (MDA) were smaller and lower when Captopril was administered by coronary sinus retroperfusion than that by systemic intravenous injection. These results suggest that (1) Captopril can be distributed adequately in the local ischemic myocardial zones when administered by coronary sinus retroperfusion in the presence of coronary artery occlusion, (2) Captopril can more effectively protect ischemic myocardium by inhibition of the ET release and against the oxygen free radicals in ischemic myocardial area when used by coronary sinus retroperfusion. |
| |
| Keywords: | myocardial infarction Captopril endothelins free radicals perfusion dog |
| 本文献已被 CNKI 等数据库收录！ |
