口腔鳞状细胞癌组织脆性组氨酸三聚体蛋白的表达及意义

目的: 检测抑癌基因脆性组氨酸三聚体（FHIT）基因在口腔鳞状细胞癌（OSCC）的表达情况，探讨其在OSCC发生过程中的作用及其意义。方法：采用免疫组织化学方法检测48例OSCC和26例正常口腔黏膜组织中FHIT的表达情况。结果: 正常黏膜的FHIT高表达，表达阳性率为76.92% (20/26)，48例OSCC中FHIT蛋白阳性表达率为43.75%，明显低于正常口腔黏膜组织（P<0.05）。FHIT的表达与年龄、性别无关(P>0.05),而与分化程度有关联,分化程度越低FHIT的表达率越低(P<0.05) 。结论: OSCC组织FHIT的表达率明显降低。FHIT对口腔癌的发生、发展起抑制作用。

Expression of FHIT in oral squamous cell carcinoma and significance

Objective To study the expression of fragile histidine triad(FHIT) in oral squamous cell carcinoma(OSCC),and discuss its role and significance in OSCC.Methods Immunohistochemical method was used to detect the expressions of FHIT in 48 cases of OSCC and 26 normal oral mucosa.Results The positive expression rate of FHIT in normal oral mucosa was 76.92%(20/26).Among 48 OSCC patients,the positive rate of FHIT(43.75%) was lower than that in normal oral mucosa(P<0.05).The expression of FHIT had no significant correlation with age and sex of patients(P>0.05),but FHIT protein content was significantly associated with differentiation(P<0.05),the poorer the differentiation,the less the expression.Conclusion The expression of FHIT is less in OSCC patients.FHIT plays an important inhibitory effect on the occurrence and development of OSCC.