| 驱虫斑鸠菊抗肿瘤化学成分的初步研究 |
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| 引用本文： | 孙力,李红健,于鲁海,尚靖,吴立军,徐建国. 驱虫斑鸠菊抗肿瘤化学成分的初步研究[J]. 中药研究与信息, 2011, 0(12): 26-28 |
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| 作者姓名： | 孙力 李红健 于鲁海 尚靖 吴立军 徐建国 |
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| 作者单位： | [1]新疆维吾尔自治区人民医院药学部,新疆乌鲁木齐830001 [2]新疆维吾尔自治区医疗机构药品采购中心,新疆乌鲁木齐830001 [3]中国药科大学,江苏南京210038 [4]沈阳药科大学,辽宁沈阳110016 |
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| 摘 要： | 目的：分离筛选驱虫斑鸠菊中具有抗肿瘤活性的化学成分。方法：利用生物活性追踪的方式，采用溶剂法、高速逆流色谱技术及柱色谱法对驱虫斑鸠菊成熟果实进行抗肿瘤化学成分的分离筛选。结果：分离并确定了4个化合物的结构，分别为紫铆素、紫铆查尔酮、5，6，7，4’-四羟基黄酮、圣草酚，其中化合物圣草酚为从该植物中首次分离获得；同时经M1Tr法测定，紫铆素和紫铆查尔酮对黑色素瘤细胞株（B16、A375）均有抑制作用，且IC50值小于10uLg·mL^-1。结论：本文结果为进一步探讨驱虫斑鸠菊药材在抗肿瘤方面的作用提供了依据。
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| 关 键 词： | 驱虫斑鸠菊 化学成分 肿瘤细胞 |
Preliminary Study on Chemical Components in Vernonia anthelmintica |
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| SUN Li,LI Hong-jian,YU Lu-hai,SHANG Jing,WU Li-jun,XU Jian-guo. Preliminary Study on Chemical Components in Vernonia anthelmintica[J]. Research & Information on Traditional Chinese Medicine, 2011, 0(12): 26-28 |
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| Authors: | SUN Li LI Hong-jian YU Lu-hai SHANG Jing WU Li-jun XU Jian-guo |
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| Affiliation: | 1. The Xinjiang Uygur Autonomous Region people＇s Hospital, Urumqi 830001 ,China; 2. The Xinjiang Uygur Autonomous Region Department of health, Urumqi 830001, China; 3. China Pharmaceutical University , Nanjing 211169, China ; 4. Shenyang Pharmaceutical University, Shenyang 110016, China) |
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| Abstract: | Objective：The antitumorous activity components were isolated from Vernonia anthelmintica Willd. Methods： Vernonia anthelmintica Willd was isolated and studied by means of HSCCC and bioactive screened method. Results： Nine compounds were obtained and they were elucidated as butin, butein, 5, 6, 7, 4＇-tetrahydroxyflavone, 5, 7, 3＇, 4＇- tetrahydroxyflavanone. The 5,7,3＇,4＇-tetrahydroxyflavanone was obtained firstly from Vernonia anthelmintica Willd. It was showed that butin and butein had inhibition of proliferation of cell lines （B16, A375）in vitro. IC50 is smaller than 10ug · mL^-1 Conclusion： The study provided the basis for the anti-tumor effect on Vernonia anthelmintica Willd. |
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| Keywords: | Vernonia anthelminticaWilld. Chemical components Tumor cell |
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