| Keratin 13基因在喉癌发生中的作用 |
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| 引用本文： | 徐振明,孙兴和,贺光,富伟能,邱广斌,赵震,孙开来.Keratin 13基因在喉癌发生中的作用[J].解放军医学杂志,2003,28(9):789-790. |
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| 作者姓名： | 徐振明 孙兴和 贺光 富伟能 邱广斌 赵震 孙开来 |
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| 作者单位： | 1. 110042,沈阳,解放军第463医院
2. 中国医科大学医学遗传教研室 |
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| 基金项目： | 国家自然科学基金 (编号 39770 794)，辽宁省教育厅基金 (编号2 0 1 2 1 0 34)资助课题 |
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| 摘 要： | 探讨keratin 13基因在喉癌发生中的作用。方法在keratin 13基因内部及附近选择5个微卫星引物进行LOH分析，于DNA水平间接检测100例喉癌患者中该基因的缺失情况。结果5个STR位点均存在LOH，其中D17S1964E、D17S2092、D17S791、D17S1665及D17S808位点的LOH频率分别为30．48％、26．02％、21．62％、37．66%和21．51％，以D17S1665位点的LOH频率最高，杂合性丢失与临床分期无显著相关。结论Keratin13基因在喉癌的发生中具有重要作用，具体机制有待进一步研究。
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| 关 键 词： | 喉肿瘤 基因，keratin 13 基因缺失 杂合子丢失 |
| 修稿时间： | 2002年12月19 |
THE EFFECT OF KERATIN 13 GENE ON LARYNGEAL CARCINOGENESIS |
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| Xu Zhenming,Sun Xinghe,He Guang et al. Hospital of PLA,Shenyang ,China.THE EFFECT OF KERATIN 13 GENE ON LARYNGEAL CARCINOGENESIS[J].Medical Journal of Chinese People's Liberation Army,2003,28(9):789-790. |
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| Authors: | Xu Zhenming Sun Xinghe He Guang Hospital of PLA Shenyang China |
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| Institution: | Xu Zhenming,Sun Xinghe,He Guang et al. 463 Hospital of PLA,Shenyang 110042,China |
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| Abstract: | Objective To investigate the role of Keratin 13 gene in laryngeal carcinogenesis. Methods To detect the deletion frequency of keratin 13 sequence indirectly by LOH analysis at DNA level using 5 STR primers within and near keratin 13 gene in 100 cases. Results LOH was found in all of the microsatellite loci, and the LOH frequencies were 30.48%, 26.02%, 21.62%, 37.66% and 21.51% at D17S1964E, D17S2092, D17S791, D17S1665, and D17S808 positions respectively. The frequencies of LOH were not related to the type of laryngeal carcinoma. Conclusion Keratin 13 gene might play an important role in the laryngeal carcinogenesis,and further research is necessary to confirm it. |
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| Keywords: | laryngeal neoplasms genes keratin 13 gene deletion loss of ieterozygosity |
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