| 红毛五加多糖对四氧化碳肝损伤保护作用机理探讨 |
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| 引用本文： | 党月兰,李淑玉. 红毛五加多糖对四氧化碳肝损伤保护作用机理探讨[J]. 中药药理与临床, 2002, 18(1): 7-8 |
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| 作者姓名： | 党月兰 李淑玉 |
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| 作者单位： | 兰州医学院药理教研室,兰州,730000 |
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| 摘 要： | 目的：研究红毛五加多糖（AGP）对四氯化碳（CCl4)肝损伤保护作用机理。方法：采用大鼠CCl4肝损伤模型进行实验。结果：AGP能明显降低CCl4肝损伤大鼠的肝MDA，提高肝GSH和细胞色素P－450含量及GSH－Px活性。结论：AGP对CCl4引起的急性肝损伤保护作用机制可能与其清除自由基，抑制脂质过氧化及诱导肝药酶有关。
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| 关 键 词： | 红毛五加多糖 四氧化碳 肝损伤 脂质过氧化 细胞色素P－450 作用机理 |
Studies on the mechanism of protective action of Acanthopanax giraldii Harms polysccharides on CCl4 injured liver in rats |
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| Dang Yuelan,Li Shuyu. Studies on the mechanism of protective action of Acanthopanax giraldii Harms polysccharides on CCl4 injured liver in rats[J]. Pharmacology and Clinics of Chinese Materia Medica, 2002, 18(1): 7-8 |
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| Authors: | Dang Yuelan Li Shuyu |
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| Abstract: | Object: To study the mechanism of protective action of Acanthopanax giraldii Harms (AGP) on CCl 4 injured liver in rats. Methods: The injured liver model induced by injection CCl 4 in rats. Results: AGP inhibited the rise of hepatic MDA content, elevated the decline of hepatic GSH and GSH Px levels and hepatocyte microsomal cytochrome P450 in CCl 4 intoxicated rats. Conclusion: The mechanism of protective action of AGP on CCl 4 injured liver is related to the clearing of free radicals and inhibition of lipid peroxidation. |
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| Keywords: | Acanthopanax giraldii Harms CCl 4 hepatic injury lipid peroxidation microsomal cytochrome P450 |
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