环糊精包合中药复方中挥发性成分研究

目的研究环糊精包合中药复方中挥发性成分的影响条件和包合物的稳定性。方法以更年复方为例，以包合物利用率为指标，考查包合工艺条件的影响因素；采用正交试验优选有关工艺参数；测定不同湿度条件下的平衡吸湿率；采用Q10法预测β-环糊精包合物的有效期。结果包合的方法、包合物用量、包合温度、包合时间、干燥方法等均能明显影响包合工艺。正交试验结果表明更年复方挥发油β-环糊精包合最佳工艺为挥发油加8倍量β-环糊精，室温下搅拌3h；稳定性试验表明湿度对包合物影响不大，包合物有效期可达1．26年。结论全面系统地考查了包合的影响因素及包合物的稳定性，为包合技术的应用和研究提供了实验依据。

Evaluation of cyclodextrin inclusion of the volatile components in compound traditional Chinese medicine

OBJECTIVE: To study the factors affecting cyclodextrin (CD) inclusion of the volatile components in compound traditional Chinese medicines and evaluate the stability of the inclusion compound. METHODS: This study took Gengnian compound as an example to examine the factors affecting the inclusion process according to the inclusion compound utilization ratio. Orthogonal design method was employed optimize the parameters in the inclusion process. The moisture absorption rate of the beta-CD inclusion compound was determined in different humidity and Q10 was used to predict its. RESULTS: The inclusion method, inclusion compound dosage, temperature, inclusion time, and the drying method could all obviously influence the inclusion process. The results of orthogonal design study showed that the optimal beta-CD inclusion of Gengnian compound volatile components could be achieved by adding 8-fold volume of beta-CD and stirring for 3 h at room temperature. Stability experiment showed that the humility did not significantly influence the inclusion compound, which can be stable for 1.26 years. CONCLUSION: This study comprehensively examines the factors affecting the inclusion process and the stability of the inclusion compound, and provides experimental basis for application and study of the inclusion technology.