吡喹酮不同化疗策略与方案对控制血吸虫病效果的研究

本文报道1980年－1996年在湖沼型重流行区吡喹酮5种化疗策略控制日本血吸虫病的效果。结果：靶人群化疗后1个月、3个月粪检阴转率均在86％以上，扩大化疗3年粪检阳性率下降74.90％，群体化疗1次和每年1次、每年2次连续2年粪检阳性率分别下降54.36％和70.19％、75.51％，阶段化疗3年粪检阳性率下降88.34％，间歇性化疗粪检阳性率下降39.34％。并对吡喹酮群体与个体化疗的剂量与疗法、不同阶段不同化疗策略的合理应用、群体化疗的对象等进行了讨论。

STUDIES ON THE EFFECTIVENESS OF VARIED CHEMOTHERAPY STRATEGIES AND SCHEDULES WITH PRAZIQUANTEL FOR SCHISTOSOMIASIS CONTROL

This peper reported the effectiveness of praziquantel with five chemotherapy strategies in the endemic area of heavy infection of schistosomiasis in the lake region in 1980- 1996.The results showed that the negative rates of stool examination were above 86%,at one and three monthes after targeted chemotherapy. The positive rate of stool examination in residents reduced by 74. 90% on extending chemotherapy for three years. Positive rates reduced by 54. 36%,70. 19% and 75. 51 % respectively on mass chemotherapy in only for once,once/year,and twice/year for three years. It reduced by 88. 34% on phased chemotherapy for three years. The rate of reduction was 39. 34% with intermittent chemotherapy. Doses and schedules of mass and individnal chemotherapy with PQT, rational application of varied chemotherapy strategies in varied stages, the object of mass chemotherapy, etc. were discussed.