Pathogenetic role of autoantibodies in neurological diseases |
| |
Authors: | Archelos J J Hartung H P |
| |
Institution: | Multiple Sclerosis Research Group, Dept of Neurology, Karl-Franzens-Universit?t, Graz, Austria. |
| |
Abstract: | Autoreactive B cells and antibodies can be detected in a variety of neurological diseases. Their causative role has been established in some disorders and they are obviously involved in the pathogenesis of others. Some mechanisms engendering B-cell autoimmunity in animal models have been shown to operate in humans. Factors that determine B-cell immune-response patterns and the effector pathways have been identified. B-cell responses to CNS-restricted autoantigens are governed by distinctive immune reactions. Evidence has accumulated that the CNS is a permissive and, under inflammatory conditions, even a B-cell-supporting micro-environment. Data from human and animal experiments have enhanced our understanding of B-cell physiology in health and neurological disease, which has relevant diagnostic and therapeutic implications. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|