血清硒水平与糖尿病关系的横断面研究

目的探讨血清硒水平与糖尿病的关系。方法采用原子吸收法检测体检人群的血硒水平。结果体检人群中,1 157名非糖尿病患者群的血硒平均水平为98.9μg/L,173名糖尿病患者的血硒水平为97.6μg/L,差异无统计学意义(P=0.578)。logistic回归分析显示,人群中3个较高血硒区间(85.8~95.9μg/L,96.0~107.9μg/L,≥108.0μg/L)相对于最低血硒区间(85.8μg/L)的糖尿病发病优势比,分别为1.00、0.72、0.96,差异无统计学意义(P0.05)。结论研究提示血硒水平为96.0~107.9μg/L时糖尿病的发病率较低,但血清硒水平与糖尿病关系尚需前瞻性队列研究的进一步证实。

A cross-sectional study on relation between serum selenium and diabetes

Objective To investigate relationship between serum selenium concentration and diabetes.Methods Atomic absorption spectrometry was used to determine serum selenium concentration.Results In population taking physical examinations,mean serum selenium concentration was 97.6μg/L and 98.9μg/L for 1 157non-diabetes individuals and 173diabetes patients,respectively,with no significant difference（P=0.578）.logistic regression analysis showed relative odds ratio for diabetes was 1.00,0.72,0.96for 3high blood selenium ranges（85.8 ~ 95.9μg/L,96.0~107.9μg/L,≥ 108.0μg/L）, compared to the lowest blood selenium interval（85.8μg/L）,respectively.Conclusions This study indicates that low diabetes morbidity was observed at serum selenium concentration range of 96.0~107.9μg/L.However,A perspective cohort study should be performed to confirm the relation of serum selenium concentration and diabetes.