| 神经损伤后外源性神经生长因子对骨骼肌钙泵活性的影响 |
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| 引用本文： | 王占友,石玉秀.神经损伤后外源性神经生长因子对骨骼肌钙泵活性的影响[J].中国医科大学学报,1998,27(6):574-576. |
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| 作者姓名： | 王占友 石玉秀 |
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| 作者单位： | Department of Histology and Embryology，School of Basic Medical Sciences，China Medical University，Shenyang，110001 |
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| 摘 要： | 目的：应用酶细胞化学技术探讨兔坐骨神经损伤后，外源性神经生长因子（ＮＧＦ）对胫骨前肌纤维钙泵活性的影响。方法：定位、定量挫伤兔右侧坐骨神经后，局部喷布ＮＧＦ，于神经损伤后第１、２、３、４、６、８周，取胫骨前肌进行Ｃａ２＋－ＡＴＰ酶细胞化学染色，透射电镜下观察钙泵活性的变化。结果：神经损伤第１～３周，肌纤维钙泵活性逐渐下降；ＮＧＦ组钙泵活性分布于６周末恢复正常；对照组于８周末恢复到正常水平。结论：周围神经损伤后，外源性ＮＦＧ对骨骼肌纤维酶活性、结构及功能的恢复具有重要作用。
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| 关 键 词： | 神经生长因子 神经损伤 骨骼肌纤维 钙泵 |
Effects of Exogenous Nerve Growth Factor on the Activity of Ca 2 pump in Skeletal Muscle Fiber after Nerve Injury |
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| Wang Zhanyou,Shi Yuxiu,Zhang Kai,et al.Effects of Exogenous Nerve Growth Factor on the Activity of Ca 2 pump in Skeletal Muscle Fiber after Nerve Injury[J].Journal of China Medical University,1998,27(6):574-576. |
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| Authors: | Wang Zhanyou Shi Yuxiu Zhang Kai |
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| Abstract: | Objective:Results:The exogenous NGF may play an important role in structural and functional recovery of skeletal muscle fiber after peripheral nerve injury. |
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| Keywords: | nerve growth factor nerve injury skeletal muscle fiber Ca 2 pump |
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