妊娠早期妇女巨细胞病毒感染状况的研究

目的：检查孕妇绒毛巨细胞病毒（ＣＭＶ）感染，了解孕妇ＣＭＶ的早期感染状况。方法：采用ＥＬＩＳＡ、ＰＣＲ、病毒分离方法检测３２例早孕妇女血清ＣＭＶ－ＩｇＭ、宫颈和绒毛ＣＭＶ－ＤＮＡ。结果：孕妇血清ＣＭＶ－ＩｇＭ阳性率９．３８％（３／３２）；宫颈ＣＭＶ－ＤＮＡ阳性率为１２．５％（４／３２）；绒毛ＣＭＶ－ＤＮＡ阳性１例，分离阳性１例，阳性率为６．２５％（２／３２）；２例绒毛ＣＭＶ感染，但血清及宫颈检查正常。结论：妊娠早期绒毛的ＣＭＶ感染率为６．２５％，母亲血清和宫颈检查正常并不能排除胎儿先天感染的可能。

Cytomegalovirus Infection in Women During Early Pregnancy

Objective:This Paper was to study the status of cytomegalovirus (CMV) infection in women at early pregnancy. Methods:We applied ELISA, PCR and virus isolation technique to detect serum CMV IgM and CMV DNA from cervical seretions as well as chorionic villi in 32 pregnant women during the first trimester. Results:The positive rate was 9.38% (3/32) for CMV IgM and 12.5% for CMV DNA (4/32) from cervical secretions. The positive rate of chorionicvilliinfectionwas6.25%(2/32), one case with positive CMV DNA and the other with positive virus isolation. But CMV was not found in sera as well as in cervix in these two cases, Conclusions:The positive rate of CMV infection was 6.25% in chorionic villi at early pregnancy which indicated that congenital infection might occur for fetus whose mother was CMV negative in serum and cervix.