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Recombinant human zona pellucida protein C produced in Chinese hamster ovary cells binds to human spermatozoa and inhibits sperm-zona pellucida interaction |
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| Authors: | Marín-Briggiler Clara I Gonzalez-Echeverría María F Harris Jeffrey D Vazquez-Levin Mónica H |
| Affiliation: | a Instituto de Biología y Medicina Experimental (IBYME), National Research Council of Argentina (CONICET), Buenos Aires, Argentina b Centro Médico Fertilab, Buenos Aires, Argentina c Zonagen Inc., The Woodlands, Texas (present address: University of California, Department of Molecular and Cell Biology, Berkeley, California) |
| Abstract: | Recombinant human zona pellucida protein C expressed in Chinese hamster ovary cells associates to the acrosomal region of human spermatozoa and inhibits sperm-zona pellucida interaction in the hemizona assay. Recombinant human zona pellucida protein C may be a useful tool toward the development of diagnostic methods for male factor infertility and the elucidation of the molecular basis of fertilization. |
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