Metformin treatment does not affect total leptin levels and free leptin index in obese patients with polycystic ovary syndrome |
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| Authors: | Romualdi Daniela Campagna Giuseppe Selvaggi Luigi Cento Rosa Proto Caterina Lanzone Antonio Guido Maurizio |
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| Affiliation: | a Department of Obstetrics and Gynecology, Università Cattolica del Sacro Cuore, Rome, Italy
b “Oasi” Institute for Research, Troina, Italy |
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| Abstract: | Leptin, particularly in its free form, is deeply involved in the regulation of energy balance. Insulin was suggested to influence plasmatic leptin levels and soluble leptin receptor in humans. However, this study indicates that metformin treatment, although improving insulin levels, does not exert a significant effect on either total leptin level or free leptin index in obese women with hyperinsulinemia and PCOS. |
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