Pregnancy outcomes of reciprocal translocation carriers who have a history of repeated pregnancy loss |
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| Authors: | Ozawa Nobuaki Maruyama Tetsuo Nagashima Takashi Ono Masanori Arase Toru Ishimoto Hitoshi Yoshimura Yasunori |
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| Institution: | a Department of Perinatal Medicine and Maternal Care, National Center for Child Health and Development, Tokyo, Japan
b Department of Obstetrics and Gynecology, School of Medicine, Keio University, Tokyo, Japan |
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| Abstract: | Cytogenetic investigation of 2,324 Japanese couples with repeated pregnancy loss revealed that 4.91% of couples (n = 114) had chromosome abnormalities including reciprocal translocation (n = 74), Robertsonian translocation (n = 23), and inversion (n = 10). Parental reciprocal translocation was a significant predictor of subsequent miscarriage (adjusted odds ratio: 3.6, 95% confidence interval: 1.8-7.1), and most of the miscarriages of the carrier couples were inevitable because of abnormal karyotypes, despite appropriate treatments. |
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