| Abstract: | ![]()
Changes in the central hemodynamics were compared with the outcome of resuscitation in 18 dogs after circulatory arrest lasting 12 min caused by ventricular fibrillation. In nine animals resuscitated with evidently complete neurological recovery moderate hypertension was observed in the first 10 min after the beginning of the resuscitation measures: The mean arterial pressure (MAP) was 175.0±8.9 mm Hg. In most of the dogs which died subsequently MAP in this period was not higher than initially, but two animals showed severe hypertension (MAP about 200 mm Hg). In this same period differences also were found in other parameters of the central hemodynamics. Moderate hypertension in the first 10 min of the postresuscitation period evidently leads to rapid recovery of an adequate level of the peripheral blood flow in tissues and organs and, as a result, it aids the survival of animals after a long period of circulatory arrest.Research Laboratory of General Resuscitation, Academy of Medical Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR V. A. Negovskii.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 88, No. 11, pp. 530–532. November, 1979. |
