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CD+4CD+25调节性T细胞与肿瘤免疫
引用本文:史红鱼,王桂琴.CD+4CD+25调节性T细胞与肿瘤免疫[J].白血病.淋巴瘤,2007,16(6):472-475.
作者姓名:史红鱼  王桂琴
作者单位:山西省儿童医院血液科,030013;山西医科大学免疫教研室
摘    要: 近期研究发现一个有独特免疫调节功能的T细胞亚群:CD+4 CD+25调节性T细胞,不仅能抑制自身免疫性疾病发生,还参与肿瘤免疫的调节。这群细胞具有免疫无能和免疫抑制特性,与肿瘤免疫逃逸有密切的关系。肿瘤环境中CD+4 CD+25调节性T细胞增加,导致肿瘤免疫失调,去除这群细胞可有效诱导肿瘤免疫,为肿瘤治疗提供了一种新的思路。

关 键 词:T淋巴细胞  肿瘤逃逸
收稿时间:2007-01-30;

CD+4CD+25regulatory T cell and tumor immunity
SHI Hong-yu,WANG Gui-qin.CD+4CD+25regulatory T cell and tumor immunity[J].Journal of Leukemia & Lymphoma,2007,16(6):472-475.
Authors:SHI Hong-yu  WANG Gui-qin
Abstract:Recently to discover a tipy of T cell subset, CD+4 CD+25 regulate T cell,which has special immunity regulating function: not only can suppress the occurrence of autoimmune diseases, but also mediate tumor immunity.This subset has immunity anergic and immunity suppressive characters,and closely relates to the tumor immunity sneaking. The increased CD+4 CD+25 regulate T cell cause the tumor immunity disorder in the tumor environment, but cleaning this subset can induce the anti-tumor immunity effectively, and provide new thinking way for the tumor therapy.
Keywords:T-lymphocytes  Tumor escape
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