| 以凋亡抑制基因为靶点的反义寡核苷酸研究现状 |
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| 引用本文： | 杨建辉,严俊,李国华. 以凋亡抑制基因为靶点的反义寡核苷酸研究现状[J]. 中国癌症杂志, 2003, 13(3): 272-274,278 |
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| 作者姓名： | 杨建辉 严俊 李国华 |
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| 作者单位： | 上海市杨浦区市东医院外科,上海,200090 |
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| 摘 要： | 抗凋亡蛋白过表达导致的凋亡抑制参与了恶性肿瘤的发生发展和化疗耐药。反义寡核苷酸可用来封闭凋亡抑制基因(如bcl-2、bcl-xL、survivin)，旨在诱导凋亡或增强化疗敏感性。联合反义寡核苷酸和传统化疗药物可能是将来癌症治疗的一种合理策略。
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| 关 键 词： | 凋亡 抑制基因 靶点 反义寡核苷酸 研究现状 恶性肿瘤 |
| 文章编号： | 1007-3639(2003)03-0272-03 |
Current status of targeting antiapoptotic gene by antisense oligodeoxynucleotides |
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| YANG Jian hui,YAN Jun,LI Guo hua. Current status of targeting antiapoptotic gene by antisense oligodeoxynucleotides[J]. China Oncology, 2003, 13(3): 272-274,278 |
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| Authors: | YANG Jian hui YAN Jun LI Guo hua |
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| Abstract: | Diminished apoptosis,due to overexpression of antiapoptotic proteins, is involved in tumorigenesis and chemoresistance. Antisense oligodeoxynucleotide (ASODN) has been used to inhibit the expression of antiapoptotic proteins(f.g bcl 2, bcl x L , survivin),aimed to induce apoptosis or enhance chemosensitivity.The combination of ASODN with conventional treatment is possibly a reasonable approach in furture cancer therapy. [ |
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| Keywords: | antisense oligodeoxynucleotide apoptosis malignancy |
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