| IFN-γ、IL-18与复发性流产的相关性研究 |
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| 引用本文： | 陈佩,孙燕,苏琳,岳锦春.IFN-γ、IL-18与复发性流产的相关性研究[J].中国妇幼保健,2012,27(13):2020-2023. |
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| 作者姓名： | 陈佩 孙燕 苏琳 岳锦春 |
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| 作者单位： | 广西医科大学第一附属医院妇产科,广西南宁,530021 |
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| 基金项目： | 广西科技厅自然科学基金资助项目〔桂科自0542084〕 |
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| 摘 要： | 目的:探讨IFN-γ和IL-18与复发性流产(RSA)发病的关系。方法:采用实时荧光定量逆转录多聚酶链式反应(RQ RT-PCR)方法测定33例RSA患者、20例正常早孕妇女绒毛组织中IFN-γ、IL-18的表达水平。结果:RSA患者绒毛IFN-γ、IL-18水平均显著高于正常早孕妇女(P<0.05),且呈正相关性(r=0.59,P<0.01)。RSA患者的流产次数与绒毛中IFN-γ、IL-18水平差异无显著性(P>0.05)。结论:IFN-γ、IL-18在复发性流产的发生机制中起一定作用。
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| 关 键 词： | 复发性流产 干扰素-γ 白细胞介素-18 实时荧光定量PCR |
Study on the correlation between interferon-γ,interleukin-18 and recurrent spontaneous abortion |
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| Institution: | CHEN Pei,SUN Yan,SU Lin et al.Department of Gynecology and Obstetrics,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,Guangxi Zhuang Autonomous Region,China |
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| Abstract: | Objective:To explore the correlation between interferon-γ,interleukin-18 and the occurrence of recurrent spontaneous abortion(RSA).Methods:Real-time fluorescence quantitative PCR was used to detect the expression levels of interferon-γ and interleukin-18 in chorionic villus samples of 33 patients with RSA and 20 normal early pregnant women.Results:The expression levels of interferon-γ and interleukin-18 in chorionic villus samples of patients with RSA were significantly higher than those of normal early pregnant women(P<0.05),and there was a positive correlation(γ=0.59,P<0.01).There was no correlation between the times of RSA and expression levels of interferon-γ and interleukin-18 in chorionic villus samples(P>0.05).Conclusion:Interferon-γ and interleukin-18 play important roles in the occurrence of RSA. |
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| Keywords: | Recurrent spontaneous abortion Interferon-γ Interleukin-18 Real-time fluorescence quantitative PCR |
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