肿瘤标志物联合检测在乳腺癌诊断中的临床意义

目的:探讨TSGF、CA153和CEA联合检测在乳腺癌诊断中的价值。方法:收集65例乳腺癌、110例乳腺良性疾病和55例健康人群血清标本。用酶联法检测TSGF,用化学发光法检测CA153和CEA。结果:TSGF、CA153和CEA对乳腺癌的敏感性为76.9%、69.2%和20.0%,特异性为64.8%、91.3%、和92.0%。联合检测乳腺癌的敏感性为87.7%,特异性为89.5%。结论:联合检测敏感性和特异性与单项检测比较均高,对乳腺癌的诊断具有重要意义。

Clinical significance of joint detection of tumor markers in diagnosis of breast cancer

Objective:To explore the values of joint detection of TSGF,CA153,and CEA in diagnosis of breast cancer.Methods:The serum samples of 65 cases with breast cancer,110 cases with breast benign diseases,and 55 normal persons were collected,ELISA was used to detect TSGF,and chemiluminescence was used to detect CA153 and CEA.Results:The sensitivities of TSGF,CA153,and CEA to breast cancer were 76.9%,69.2%,and 20.0%,respectively.The specificities of TSGF,CA153,and CEA to breast cancer were 64.8%,91.3%,and 92.0%,respectively.The sensitivity and specificity of joint detection were 87.7% and 89.5%,respectively.Conclusion:Compared with single detection of TSGF,CA153,and CEA,the sensitivity and specificity of joint detection are high,which have important significances for diagnosis of breast cancer.