卡介苗预防儿童结核性脑膜炎效果病例对照研究

目的:讨论卡介苗保护儿童结核性脑膜炎(结脑)的效果,探讨儿童现行卡介苗(BCG)免疫策略。方法:严格采用病例对照研究方法,对入选结脑病例和对照进行调查,以Epi Info流行病学软件建立数据库,进行相应分析,据此测算疫苗效力(VE)。结果:入选42例病例及126例对照。接种BCG(χ2=25.487 3,P=0.000 0)与儿童结脑发病有统计学关联,BCG的VE=89.42%,95%可信区间(CI)为(69%,97%)。结论:接种BCG是儿童结脑保护因素,保护率89.24%。建议继续推行卡介苗免疫策略,以保护儿童免受结脑等重症结核的侵袭。

Effect of BCG on prevention of tubercular meningitis in children: a case-control study

Objective:To discuss the protective effect of BCG on tubercular meningitis in children,explore the immune strategy of current BCG in children. Methods:A case-control study method was used to survey the children with tubercular meningitis(case group) and the children in control group,Epi Info epidemical software was used to establish database,corresponding analysis was performed to calculate vaccine efficacy(VE). Results:A total of 42 children in case group and 126 children in control group were included into the study.There was a correlation between BCG inoculation and the incidence of tubercular meningitis in children(χ2=25.487 3,P=0.000 0),VE of BCG was 89.42%,95% confidence interval(CI) was 69%-97%. Conclusion:BCG inoculation is a protective factor of tubercular meningitis in children,the protective rate was 89.24%.It is recommended to carry out BCG immune strategy to avoid children from invasion of severe tuberculosis,such as tubercular meningitis.