多囊卵巢综合征不孕症患者的促排卵治疗临床分析

目的:探讨应用盐酸二甲双胍配合促排卵药治疗多囊卵巢综合征(PCOS)引起不孕的临床效果。方法:选择该院不孕症门诊就诊的患者,分成PCOS组102例,调月经周期同时服盐酸二甲双胍2～3个月后,促排卵治疗;非PCOS组490例,对月经不调和有内分泌疾病的患者调月经周期同时治疗内分泌疾病2～3个月后,促排卵治疗。观察治疗后的妊娠率、卵巢过度刺激综合征(OHSS)发生率、多胎妊娠和早期流产发生情况。结果:PCOS组的妊娠率、OHSS发生率明显高于非PCOS组,P<0.01;多胎发生情况也高于非PCOS组,P<0.01;早期流产的发生无明显差异,P>0.05。结论:盐酸二甲双胍配合促排卵治疗多囊卵巢综合征引起不孕的临床效果较好,能明显提高妊娠率,OHSS发生率在15%～16%,且程度较轻,结局良好。但是PCOS不孕患者促排卵时OHSS的发生和多胎妊娠很难完全避免。

Clinical analysis on ovulation induction for infertile patients with polycystic ovary syndrome

Objective:To explore the clinical efficacy of metformin hydrochloride combined with ovulation induction for treatment of infertility caused by polycystic ovary syndrome(PCOS).Methods:The infertile patients from outpatient department of infertility of the hospital were selected and divided into PCOS group(102 cases) and non-PCOS group(490 cases),the cases in PCOS group were treated with regulating menstrual cycle and oral administration of metformin hydrochloride for 2-3 months combined with ovulation induction;while the cases with abnormal menstruation and endocrine diseases in non-PCOS group were treated with regulating menstrual cycle and curing endocrine diseases for 2-3 months combined with ovulation induction.The pregnancy rates,the incidences of ovarian hyperstimulation syndrome(OHSS),the rates of multiple pregnancy,and the incidences of early abortion after treatment in the two groups were observed.Results:The pregnancy rate,the incidence of OHSS,and the rate of multiple pregnancy in PCOS group were statistically significantly higher than those in non-PCOS group(P<0.01);there was no statistically significant difference in the incidence of early abortion between the two groups(P>0.05).Conclusion:The clinical efficacy of metformin hydrochloride combined with ovulation induction for treatment of infertility caused by PCOS was good,the therapy can improve pregnancy rate significantly;the incidence of OHSS was 15%-16%,the degree was mild,and the outcome was good.But it is difficult to avoid OHSS and multiple pregnancy completely for infertile patients with PCOS during the course of ovulation induction.