人工流产术前不同剂量米索前列醇阴道置入临床效果评价

目的:探讨人工流产术前不同剂量米索前列醇阴道置入的临床效果。方法:将180例人工流产患者随机分为3组,A组术前给予200μg米索前列醇阴道置入,B组给予400μg米索前列醇阴道置入,对照组术前无药物置入。比较3组宫口扩张程度、手术时间、术中出血量、人工流产综合征发生率及药物不良反应等情况。结果:对照组、A组及B组宫口扩张总有效率分别为58.3%、95.0%和98.3%,差异有统计学意义(P<0.05);对照组、A组及B组手术时间、术中出血量、人工流产综合征发生率依次降低(P<0.05);A组和B组药物不良反应发生率分别为1.7%和3.3%,差异无统计学意义(P>0.05)。结论:人工流产术前阴道置入米索前列醇有利于宫口充分扩张、缩短手术时间,400μg米索前列醇效果更为理想,且不增加药物不良反应。

Evaluation of clinical effect of transvaginal application of different doses of misoprostol before artificial abortion

Objective:To explore the clinical effect of transvaginal application of different doses of misoprostol before artificial abortion.Methods:One hundred and eighty patients with artificial abortion were randomly divided into three groups,the patients in group A were treated with transvaginal application of misoprostol(200 μg),the patients in group B were treated with transvaginal application of misoprostol(400 μg),while the patients in control group didn’t receive misoprostol.The degree of cervical dilation,the operation time,the amount of blood loss during operation,the incidence of induced abortion syndrome,and adverse reactions in the three groups were compared.Results:The total effective rates of cervical dilation in control group,group A,and group B were 58.3%,95.0%,and 98.3%,respectively,there was significant difference among the three groups(P<0.05);the operation times,the amounts of blood loss during operation,the incidences of induced abortion syndrome in control group,group A,and group B decreased successively,there was significant difference(P<0.05);the incidences of adverse reactions in group A and group B were 1.7% and 3.3%,respectively,there was no significant difference between the two groups(P>0.05).Conclusion:Transvaginal application of misoprostol before artificial abortion is helpful to sufficient dilation of cervix,which can shorten operation time,the effect of 400 μg misoprostol is ideal,and it doesn’t increase adverse reactions.