妊娠期高血压疾病对新生儿食欲素水平的影响及其意义

目的:探讨妊娠期高血压疾病(hypertensive disorder in pregnancy,HDP)对新生儿脐血食欲素水平的影响及食欲素与新生儿出生体质量、体质量指数、头围、身长之间的关系。方法:妊娠期高血压疾病母亲所生新生儿65例,按第7版妇产科学妊娠期高血压疾病诊断标准分为3组:妊娠期高血压组(HDP 1)24例、子痫前期轻度组(HDP 2)23例、子痫前期重度组(HDP 3)18例,正常对照组41例。采用放射免疫分析法(Radioimmunoassay RIA)测定脐血食欲素水平,并分析食欲素水平与新生儿出生体质量、体质量指数(Birth Mass Index BMI)、头围、身长的相关性。结果:①妊娠期高血压疾病组新生儿脐血食欲素水平高于正常对照组,且随母亲妊娠期高血压疾病程度的加重呈进行性升高,组间比较有统计学意义(F=3.962,P<0.05)。②妊娠期高血压疾病组新生儿出生体质量、体质量指数低于正常对照组,且随母亲妊娠期高血压疾病程度的加重呈进行性下降,组间比较有统计学意义(F=6.141,P<0.01;F=2.678,P<0.05);头围、身长组间比较有统计学意义(F=5.483,P<0.01;F=6.352,P<0.01),表现为子痫前期重度组新生儿头围、身长明显低于正常对照组。③妊娠期高血压疾病组新生儿脐血食欲素水平与出生体质量、体质量指数、头围、身长均呈负相关(r=-0.342,P<0.05;r=-0.317,P<0.05;r=-0.334,P<0.05;r=-0.287,P<0.05)。结论:妊娠期高血压疾病母亲所生新生儿脐血中存在食欲素,食欲素水平随母亲妊娠期高血压疾病程度的加重而进行性升高,食欲素与胎儿生长发育明显相关。

Affect of hypertensive disorder in pregnancy(HDP)on the level of neonates orexin and its significance

Objective:To study the affect of HDP on the level of neonates orexin and the relationship between the orexin and birth weight,birth mass index(BMI),head circumference,body length. Methods:Sixty-five neonates whose mothers had HDP were devided into three groups according to the diagnostic standard of the seventh published Obstetric Gynecology: HDP group(24 cases),longitudinal pre-eclampsia group(23 cases),serous pre-eclampsia group(18 cases).Another 41 normal neonates were taken as controled group.Orexin concentrations was measured by Radioimmunoassay(RIA)and the relationships between orexin and birth weight,BMI,head circumference,body length were analyzed. Results:① Orexin concentrations in HDP group were higher than the control group,and they went up gradually following grades of mother′s gestational hypertension,there was statistical significance among groups(F=3.962,P<0.05).② Birth weight,BMI in HDP group were lower than the control group,and they went down gradually following grades of mother′s HDP,there was statistical significant among groups(F=6.141,P<0.01;F=2.678,P<0.05);Head circumference,body length ware statistical significant among groups(F=5.483,P<0.01;F=6.352,P<0.01),it shown that head circumference,body length of serous pre-eclampsia group were remarkble lower than the control group.③ Orexin concentrations in HDP group had negative relationship with birth weight,BMI,head circumference,body length(r=-0.342,P<0.05;r=-0.317,P<0.05;r=-0.334,P<0.05;r=-0.287,P<0.05). Conclusion:There are orexin in the cord blood of neonates whose mother have HDP,and orexin concentrations are higher than the normal newborns,and they go up gradually following grades of mother′s gestational hypertension;orexin concentrations have a positively correlation with growth and development of perinatal fetus.