小儿咳嗽变异性哮喘分期治疗的临床研究

目的:探讨小儿咳嗽变异性哮喘的临床分期治疗效果。方法:选择该院自2010～2011年呼吸科治疗的120例咳嗽变异性哮喘患儿,按照患者就诊的时间先后顺序,将患者随机分为观察组(分期治疗组)、对照组(未分期治疗组),每组60例。对照组口服富马酸酮替芬片及静脉滴住氨茶碱注射液,观察组中患者急性发作期口服富马酸酮替芬片,静脉滴注氨茶碱注射液;慢性持续期口服富马酸酮替芬片;临床缓解期静脉滴住氨茶碱注射液,7天为1个疗程,连续3个疗程后观察两组临床疗效、肺功能、临床症状改变情况及安全性进行对比分析。结果:观察组与对照组治疗后的临床疗效分别为90.00%(54/60),81.67%(49/60);观察组日间症状评分≤2分的患者46例,夜间症状≤2分的患者41例,对照组日间症状评分≤2分的患者34例,夜间症状≤2分的患者32例,两组比较差异有统计学意义(P<0.05)。结论:分期治疗咳嗽变异性哮喘患儿可减轻了患儿及其家属的痛苦,提高了患者的生活质量,具有非常巨大的社会意义,同时也会获得很好的社会效益和经济效益。

Clinical study on stage treatment for the infants with cough variant asthma

Objective:To explore the curative effect of stage treatment for the infants with cough variant asthma.Methods:One hundred and twenty infants with cough variant asthma who were treated in pulmonary department of the hospital from 2010 to 2011 were selected,then they were ranked according to the time they visited the hospital,all the infants were divided into observation group(including the infants treated with stage treatment) and control group(including the infants without stage treatment),60 infants in each group.The infants in control group were treated with oral administration of ketotifen fumarate tablets and intravenous drip of aminophylline injection;while the infants in observation group were treated with oral administration of ketotifen fumarate tablets and intravenous drip of aminophylline injection during acute attack period,oral administration of ketotifen fumarate tablets during chronic persistent period,and intravenous drip of aminophylline injection during clinical remission period.Seven days were designed as one course of treatment,clinical curative effects,pulmonary functions,clinical symptoms,and safeties in the two groups were observed and compared after three courses of treatment.Results:After treatment,the clinical curative effects in observation group and control group were 90.00%(54/60) and 81.67%(49/60),respectively.In observation group,46 cases with the daytime symptom score ≤2 and 41 cases with the nighttime symptom score ≤2 were found;while in control group,34 cases with the daytime symptom score ≤2 and 32 cases with the nighttime symptom score ≤2 were found,there was significant difference between the two groups(P<0.05).Conclusion:Stage treatment can relieve the pains of infants with cough variant asthma and their parents,improve the quality of life of the infants,the therapy has great social significance,and it also get good social benefits and economic benefits.