平均红细胞体积在筛查孕妇地中海贫血中的临床应用分析

目的:探讨平均红细胞体积在筛查孕妇地中海贫血中的临床应用及意义。方法:选取中山市中医院2006～2010年5 000例开展地中海贫血筛查的孕妇,观察平均红细胞体积在筛查中的检测率,并参照基因诊断得出该指标的特异性。结果:依据平均红细胞体积参数指标,5 000例孕妇地中海贫血筛查后检出468例,检出率为9.36%。460例得到确诊,特异性为98.29%。结论:平均红细胞体积在筛查孕妇地中海贫血中具有积极的临床意义,能提高产前检查和孕期体检中疾病检出率,减少重型地贫儿的出生率、降低围生儿病死率,减少孕妇并发症。

Analysis on clinical application of mean corpuscular volume in screening of thalassemia among pregnant women

Objective:To explore the clinical application and significance of mean corpuscular volume in screening of thalassemia among pregnant women. Methods:A total of 5 000 pregnant women who received thalassemia screening in the hospital from 2006 to 2010 were selected,the detection rate of mean corpuscular volume during screening was observed,then the specificity of the index was obtained according to genetic diagnosis. Results:According to mean corpuscular volume index,468 pregnant women were screened out among 5 000 pregnant women,the detection rate of thalassemia was 9.36%.A total of 460 pregnant women were diagnosed definitely,the specificity was 98.29%. Conclusion:Mean corpuscular volume has positive clinical significance in screening of thalassemia among pregnant women,which can improve prenatal examination rate and detection rate of diseases during gestational physical examination,reduce the birth rate of neonates with severe thalassemia,fatality rate of perinatal infants,and maternal complications.