西宁地区儿童甲型H1N1流感血清抗体水平调查

目的:了解流行期西宁地区儿童甲型H1N1流感病毒抗体水平的变化趋势和特点。方法:在青海省儿童医院随机选择就诊儿童747例,采集静脉血进行甲型H1N1流感血清抗体水平检测和分析。结果:调查期间儿童总体阳性率为42.97%,GMT水平为1∶23.92。疫苗接种人群的阳性率和GMT水平为93.75%和1∶54.33,明显高于未接种疫苗人群的36.88%和1∶19.83。非疫苗免疫儿童中,9～岁、12～岁年龄组抗体阳性率和GMT水平最高,0～岁年龄组最低,并且随年龄增长呈增高趋势(P<0.01)。结论:经过流行期后,西宁地区儿童已经形成一定的保护屏障,但婴幼儿保护性抗体比例仍然较低,提示该人群是今后甲型H1N1流感重点保护的对象。

Investigation on the level of serum influenza A antibody in children in Xining

Objective:To understand the change trend and characteristics of influenza A(H1N1) antibody level in children in Xining during epidemic period.Methods:A total of 747 children who were treated in Qinghai children’s hospital were selected randomly,then venous blood specimens were collected to detect and analyze the serum level of H1N1 antibody.Results:Among the children investigated,the total positive rate of H1N1 antibody was 42.97%,the level of GMT was 1∶ 23.92.The positive rate of H1N1 antibody and GMT level in the population receiving vaccine inoculation were 93.75% and 1∶ 54.33,respectively,which were significantly higher than those in the population without vaccine inoculation(36.88% and 1∶ 19.83,respectively).Among the children without vaccine planned immunization,the positive rate of H1N1 antibody and GMT level in 9-age group and 12-age group were the highest,while the positive rate of H1N1 antibody and GMT level in 0-age group was the lowest,showing an increasing trend with age(P<0.01).Conclusion:The children in Xining had a certain protective barrier after epidemic period,but the proportion of infants with protective antibody was still low.Which indicates that the infants were the key protection objects against H1N1.