首发精神分裂症患者脂质过氧化物及抗氧化酶水平的研究

目的：探讨氧化应激在精神分裂症发病中的作用。方法：对首发且未服药的精神分裂症患者40例,行简明精神病评定量表（BPRS）评定,并测定氧化应激相关指标。药物治疗12周后,再次进行上述检测。取40例健康志愿者外周血,检测相同生化指标。结果：患者组丙二醛（MDA）和过氧化氢酶（CAT）较对照组显著升高（P〈0.01）,而超氧化物歧化酶（SOD）及谷胱甘肽过氧化物酶（GSH-Px）显著降低（P〈0.01）。治疗后MDA和CAT较治疗前显著降低（P〈0.01）,而SOD及GSH-Px显著升高（P〈0.01）。结论：精神分裂症患者处于氧化应激状态,自由基增加,抗氧化能力降低,这些可能与精神分裂症的病理机制有关。

Study on the levels of lipid peroxide and antioxidant enzymes in first-episode schizophrenic patients

Objective：To explore the function of oxidative stress in the etiology of schizophrenia.Methods：Forty first episode schizophrenic patients were recruited and assessed with BPRS.MDA,SOD,CAT and GSH-Px in plasma were de tected before and after treatment compared with matched control.Results：The average levels of MDA and CAT in patients were increased than that in control group（P〈0.01）,while SOD and GSH-Px were decreased（P〈0.01）.The concentrations of MDA and CAT after treatment were lower than that without treatment（P〈0.01）and SOD and GSH-Px were higher（P〈0.01）.Conclusion：There is serious deregulation of oxidative and anti-oxidative metabolism system in schizophrenic patients.Both of increased free radicals and decreased anti-oxidative capacity may be relevant to the pathophysiology of schizophrenia.