麻杏甘石汤及其配伍抗急性肺损伤的实验研究

目的：探讨麻杏甘石汤及其配伍抗急性肺损伤的药效作用及作用机理，为其治疗实验性急性损伤提供药理学证据。方法：以正交设计法设计实验，以LPS尾静脉注射制作大鼠急性肺损伤模型，观察麻杏甘石汤及其不同配伍对实验模型的影响，以揭示麻杏甘石汤抗急性肺损伤的配伍规律。结果：麻杏甘石汤及其配伍具有良好的抗急性肺损伤的药效作用。其作用机制可能与降低血清升高的TNF-α及升高血清降低的IL-10有关；实验结果还表明药效作用都以全方组最好，君药对以上各试验的影响都最大。结论：麻杏甘石汤具有良好的防治SIRS—AI的作用；君药在方中起主要的治疗作用。臣药与佐使药则可增强相关的药理效应。

The Empirical Study of Maxingganshi Decoction and It's Compatibility in Acute Lung Injury Rats

OBJECTIVE: To explore the pharmacodyniamic action and the mechanism of action of the Maxingganshi decoction in acute lung injury rats in order to supply the pharmacology evidence to cure the SIRS-ALI of Maxingganshi decoction. METHODS: The study designed by orthogonal design. The SIRS-ALI model were Conseructed by the LPS intravenous injection and the effects of Maxingganshi decoction and it's different compatibilities to the SIRS-ALI model were observed. The experiments results were analvsised in order to reveal the compatibility rules of the Maxingganshi decocotion. RESULTS: Maxingganshi decocotion and its different compatibilities had good effects of prevention and cure the SIRS-ALI. The mechanism maybe concerned with the Maxingganshi decocotion can decrease the TNF-alpha and increase the IL-10. The experiments results also indicated that the action of the full formula was the best. The principal drug was the most important in the formula. CONCLUSION: Maxingganshitang has a good effect in anti the ALI; the results indicat that the principal drug is the predominant therapeutic action in the formula ministerial drug. Adjuvant drug and messenger drug can strengthen pharmacodynamic action.