儿童哮喘病遗传流行病学研究

目的　探讨遗传因素在儿童哮喘病发病中的作用。方法　用病例对照的研究方法，确定了１８６ 例哮喘患儿为先证者，收集了１８６ 对核心家系的资料进行了遗传流行病学研究。结果儿童哮喘病具有明显家族聚集性（χ２ ＝ ２４ ．８０ ，Ｐ＜ ０ ．０１） ，先证者Ⅰ、Ⅱ级亲属哮喘病患病率（ 分别为１３ ．６８ ％ 和５ ．３０ ％ ） 明显高于对照组（１ ．９６ ％ ） 。哮喘病分离比为０ ．１４ ，９５ ％ 可信限为０ ．０９７ ～０ ．１８ ，哮喘病Ⅰ、Ⅱ级亲属遗传度分别为７８ ．１８ ％ 和５５ ．０２ ％ ，且女性亲属遗传度（８３ ．６４ ％ ） 明显高于男性（７３ ．４８ ％ ） 。结论　哮喘病属多基因遗传方式，遗传因素是儿童哮喘病的主要危险因素，且对女性更明显

A study of genetic epidemiology on child bronchial asthma

OBJECTIVE: To examine the relationship between child bronchial asthma and genetic fastor. METHODS: A case-control study including 372 pedigree was carried out. RESULTS: Child bronchial asthma had obvious familiar clustering (chi 2 = 24.8, P < 0.01). The prevalence rate of the first and the second degree relatives of proband was significally higher than that of the controls. The segregation ration of asthma was 0.14 (95% CL 0.098-0.18). The h2 of the first and second degree relatives of asthma were 78.18% and 55.02%, of which 83.64% for female and 73.48% for male. CONCLUSION: The genetic model of asthma belonged to polygenetics. Genetic fastor was a main risk fastor for asthma, especially for female patients.