农村成年居民幽门螺杆菌感染的血清流行病学调查

目的　探讨农村成年居民幽门螺杆菌（Ｈｐ） 感染情况及其与血清胃蛋白酶原Ⅰ（ＰＧⅠ） 、胃蛋白酶原Ⅱ（ＰＧⅡ） 和胃泌素（ＧＡＳ） 水平的关系。方法　以ＥＬＩＳＡ 方法对赞皇县１ ５０４ 名３０岁以上居民血清Ｈｐ 抗体进行了检测，同时以放射免疫学方法对该组调查对象血清ＰＧⅠ、ＰＧⅡ、ＰＧⅠ／ＰＧⅡ比值和ＧＡＳ水平进行了定量分析。结果　赞皇县农村成年居民血清Ｈｐ 抗体阳性率为６６．４％ ，在性别之间阳性率差异无显著性。在不同年龄组的居民中，３０ ～５０ 岁和７０ 岁以上组血清Ｈｐ 抗体阳性率有增高趋势，但统计学意义不明显。胃癌高发区和相对低发区居民血清Ｈｐ 抗体阳性率差异不明显。血清Ｈｐ ＩｇＧ抗体阳性居民血清ＰＧⅠ、ＰＧⅡ和ＧＡＳ水平（６２ ．３μｇ／Ｌ，１５ ．４５μｇ／Ｌ，７４．００ｐｇ／ｍｌ） 均明显高于ＨｐＩｇＧ抗体阴性者（４２ ．１μｇ／Ｌ，６ ．４０μｇ／Ｌ，６６．００ｐｇ／ｍｌ） ，Ｐ＜ ０．００５ ，而血清ＰＧⅠ／ＰＧⅡ比值则显著低于后者（４．０∶６．６ ，Ｐ＜ ０．００５） 。结论　赞皇县大部分农村成年居民有Ｈｐ 感染；Ｈｐ 感染可影响血清ＰＧ和ＧＡＳ水平。

Seroepidemiological study on Helicobactor pylori infection in rural adult residents

OBJECTIVE: To study the prevalence of Helicobactor pylori (Hp) infection in rural adult residents of China and its relation to serum levels of pepsinogen I (PG I), pepsinogen II (PG II) and gastrin (GAS). METHODS: Serum levels of antibodies against Hp were determined with enzyme-liked immunosorbent assay (ELISA) in 1,504 residents aged over 30 in Zanhuang County of Hebei Province, and their serum levels of PG I, PG II and GAS, as well as PG I/PG II ratio, were analyzed quantitatively, with radioimmunoassay (RIA). RESULTS: Positivity for serum Hp antibody accounted for 66.4% of the rural adults in Zanhuang County, without significant sex difference. There was no significant difference in positivity for serum Hp antibody between residents in the high and low prevalent areas of gastric cancer. Serum levels of PG I, PG II and GAS were significantly higher in those with positive serum IgG anti-Hp (62.3 micrograms/L, 15.45 micrograms/L and 74.00 pg/ml, respectively) than those negative (42.1 micrograms/L, 6.40 micrograms/L and 66.00 pg/ml, respectively), all with a P-value less than 0.005, and the ratio of serum PG I to PG II levels was significantly lower in the former (4.0) than that in the latter (6.6), with P < 0.005. CONCLUSION: More than two thirds of the adult residents in Zanhuang County had infected with Hp, which could affect their serum levels of PG and GAS.