成都地区女性乳腺癌危险因素的病例对照研究

目的　调查成都地区女性乳腺癌危险因素,为确定高危人群、提出预防措施提供依据。方法　对过去3年中成都地区经病理证实的乳腺癌265例进行1∶1配对病例对照研究。结果在单因素分析中,达到显著性水平的危险因素为行经期≥35年、服用避孕药、良性乳腺疾病史、被动吸烟及常食用蜂王浆等,达到显著性水平的保护因素为哺乳及常食豆类食品。条件logistic多元回归分析显示,重要的有统计学显著意义的乳腺癌危险因素是良性乳腺疾病史、被动吸烟,重要保护性因素是常食豆制品及哺乳。结论　成都地区女性乳腺癌重要危险因素为良性乳腺疾病史及被动吸烟。

Matched case-control study for detecting risk factors of Breast Cancer in women living in Chengdu

OBJECTIVE: To detect the risk factors of breast cancer in women living in Chengdu in order to identify high risk population and to conduct proper interventions. METHODS: A matched case-control study was performed in 265 cases with breast cancer who lived in this area. RESULTS: In the univariate analysis, menarche to menopause period > or = 35 years, taking oral contraceptives, history of benign breast diseases, passive smoking, and syrup drinking are the statistically significant risk factors of breast cancer, whereas breast feeding and soybean food consumption are protective factors. Conditional logistic multivariate analysis revealed that history of benign breast diseases and passive smoking are risk factors while soybean food products and breast feeding are protective factors. CONCLUSION: The risk factors of breast cancer in women living in Chengdu are history of benign breast diseases and passive smoking.