1080例吸毒者HDV及合并HBV感染情况分析

目的:了解吸毒者丁型肝炎病毒及合并乙型肝炎病毒感染情况。方法:对我所2004年9月-2005年1月新收容的1080例吸毒者进行丁型肝炎病毒抗体(HDV-IgG)及HDV-IgG合并乙型肝炎表面抗原(HBsAg)检测,并用自行设计的《吸毒方式调查表》进行问卷调查。结果:在1080例吸毒者中,HDV感染156例,感染率14.4%,其中静脉注射者153例(98.1%);静脉注射组的HDV感染率15.9%(153/960),高于烫吸组(2.5%,3/120),P<0.01;在静脉注射组的HDV感染者中,共用注射器者的比例(21.3%,132/620)高于非共用注射器者(6.9%,21/340),P<0.001;在156例HDV感染者中有145例合并HBV感染,且合并者的肝功异常率高达73.1%(106/145)。结论:吸毒者中HDV感染率较高,且绝大多数合并HBV感染。共用注射器吸毒是导致HDV及HBV感染的主要原因,有关部门应采取有力措施,做好预防工作。

ANALYSIS OF HDV AND COMPLICATED BY HBV INFECTION AMONG 1080 DRUG ABUSERS

Objective: To investigate HDV and complicated by HBV infection among drug abusers. Methods: HBsAg and HDV-IgG serum antibody of 1080 drug abusers recruited for drug rehabilitation from September,2004 to January,2005 were tested and analyzed.Self-designed questionnaires were adopted for the survey of drug abuse routes. Results: Of the 1080 drug abusers,there were 156(14.4%) HDV infected cases,including 153(98.1%) intravenous drug abusers(IDUS),accounting for 15.9% of IDUS(960 cases),and 3 non-injecting drug users,accounting for 2.5%(3/120)showing significant difference(P<0.01).The rate of HDV infections in those who shared needles was 21.3%(132/620),which was higher than that(6.9%) who did not share(21/340),P<0.001.Of the 156 HDV infected cases,145 cases were complicated by HBV,and among them 73.1%(106/145) had abnormal liver function. Conclusion: The rate of HDV infection in drug abusers is high and most of them are infected by HBV too.Sharing needles is the main reason of HDV and HBV transmission,which calls on attention to take measures to prevent it.