| 鲍曼不动杆菌主动外排系统adeR基因分布及耐药性分析 |
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| 引用本文： | 蔡燕,曾丽红,潘雪,梁奕,彭乙华,青鑫,何城,张婷,黄义山. 鲍曼不动杆菌主动外排系统adeR基因分布及耐药性分析[J]. 检验医学与临床, 2019, 16(4): 438-440 |
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| 作者姓名： | 蔡燕 曾丽红 潘雪 梁奕 彭乙华 青鑫 何城 张婷 黄义山 |
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| 作者单位： | 川北医学院附属医院检验科, 四川南充 637000;川北医学院医学检验系, 四川南充 637000;川北医学院转化医学研究中心, 四川南充 637007;川北医学院医学检验系,四川南充,637000;川北医学院附属医院内分泌科,四川南充,637000;川北医学院附属医院检验科, 四川南充 637000;川北医学院医学检验系, 四川南充 637000 |
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| 摘 要： | 目的通过检测外排泵基因adeR在鲍曼不动杆菌中的分布及对临床常用抗菌药物的药敏情况,初步探讨外排泵对鲍曼不动杆菌耐药性的影响。方法采用聚合酶链反应(PCR)检测84株鲍曼不动杆菌外排泵基因adeR的分布情况,并根据PCR结果将菌株分为adeR基因阳性组和adeR基因阴性组,比较两组鲍曼不动杆菌对阿米卡星、头孢吡肟、左氧氟沙星和亚胺培南的耐药率。结果 PCR结果显示,收集的鲍曼不动杆菌adeR基因阳性率为70.24%(59/84);adeR基因阳性组对阿米卡星、头孢吡肟、左氧氟沙星和亚胺培南的耐药率分别为83.93%、90.74%、84.75%和67.80%;adeR基因阴性组对各抗菌药物的耐药率分别为58.33%、73.91%、56.00%和44.00%;两组间耐药率比较,差异有统计学意义(P<0.05)。结论外排泵基因adeR在该地区鲍曼不动杆菌中的检出率较高,与临床常用抗菌药物耐药情况高度相关,提示外排系统是该地区鲍曼不动杆菌多重耐药的重要原因之一。
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| 关 键 词： | 鲍曼不动杆菌 耐药 外排泵 adeR基因 |
Active efflux system gene adeR distribution of Acinetobacter baumannii and drug resistance analysis |
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| CAI Yan,ZENG Lihong,PAN Xue,LIANG Yi,PENG Yihua,QING Xin,HE Cheng,ZHANG Ting,HUANG Yishan. Active efflux system gene adeR distribution of Acinetobacter baumannii and drug resistance analysis[J]. Laboratory Medicine and Clinic, 2019, 16(4): 438-440 |
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| Authors: | CAI Yan ZENG Lihong PAN Xue LIANG Yi PENG Yihua QING Xin HE Cheng ZHANG Ting HUANG Yishan |
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| Affiliation: | (Department of Clinical Laboratory,Affiliated Hospital of North Sichuan Medical College,Nanchong,Sichuan 637000,China;Department of Endocrinology,Affiliated Hospital of North Sichuan Medical College,Nanchong,Sichuan 637000,China;Faculty of Medical Laboratory,North Sichuan Medical College,Nanchong,China 637007;Translational Medicine Research Center,North Sichuan Medical College,Nanchong,China 637007) |
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| Abstract: | CAI Yan;ZENG Lihong;PAN Xue;LIANG Yi;PENG Yihua;QING Xin;HE Cheng;ZHANG Ting;HUANG Yishan(Department of Clinical Laboratory,Affiliated Hospital of North Sichuan Medical College,Nanchong,Sichuan 637000,China;Department of Endocrinology,Affiliated Hospital of North Sichuan Medical College,Nanchong,Sichuan 637000,China;Faculty of Medical Laboratory,North Sichuan Medical College,Nanchong,China 637007;Translational Medicine Research Center,North Sichuan Medical College,Nanchong,China 637007) |
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| Keywords: | Acinetobacter baumannii multidrug resistance efflux pump adeR gene |
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