| 银屑病合并代谢综合征患者血清脂蛋白相关磷脂酶A2及炎性因子变化的意义 |
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| 引用本文： | 居峰,钱雷,郑任山,于建秀. 银屑病合并代谢综合征患者血清脂蛋白相关磷脂酶A2及炎性因子变化的意义[J]. 检验医学与临床, 2019, 16(3): 323-326 |
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| 作者姓名： | 居峰 钱雷 郑任山 于建秀 |
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| 作者单位： | 江苏省盐城市建湖县人民医院检验科,224700;江苏省盐城市滨海县人民医院检验科,224500;江苏省盐城市滨海县人民医院皮肤科,224500 |
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| 基金项目： | 南京医科大学江苏康达医药卫生发展研究院科研立项 |
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| 摘 要： | 目的通过检测银屑病患者血清脂蛋白相关磷脂酶A2(Lp-PLA2)及相关炎性因子的水平,探讨其在银屑病合并代谢综合征(MS)过程中的作用。方法收集60例银屑病患者及60例非银屑病对照者血清,组内根据是否合并MS分为银屑病无MS组、银屑病合并MS组、非银屑病无MS组、非银屑病合并MS组。通过化学发光法检测Lp-PLA2水平,免疫比浊法检测血清C-反应蛋白(CRP)水平;采用酶联免疫吸附试验(ELISA)检测脂联素、瘦素和抵抗素水平。结果与非银屑病组相比,银屑病组患者血清Lp-PLA2、瘦素、抵抗素及CRP水平升高(P<0.05);与非银屑病合并MS组相比,银屑病合并MS组血清Lp-PLA2、CRP、瘦素及抵抗素水平升高(P<0.05),脂联素水平降低(P<0.05);与非银屑病无MS组相比,银屑病无MS组患者血清Lp-PLA2水平升高(P<0.05);与银屑病无MS组相比,银屑病合并MS组血清瘦素水平明显升高(P<0.05),脂联素水平明显降低(P<0.05)。结论银屑病合并MS疾病过程中Lp-PLA2、CRP、瘦素、抵抗素水平升高,脂联素水平降低。
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| 关 键 词： | 银屑病 代谢综合征 脂蛋白相关磷脂酶A2 炎性因子 |
Change and significance of serum LP-PLA2 and inflammatory factors in patients with psoriasis complicating metabolic syndrome |
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| JU Feng,QIAN Lei,ZHENG Renshan,YU Jianxiu. Change and significance of serum LP-PLA2 and inflammatory factors in patients with psoriasis complicating metabolic syndrome[J]. Laboratory Medicine and Clinic, 2019, 16(3): 323-326 |
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| Authors: | JU Feng QIAN Lei ZHENG Renshan YU Jianxiu |
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| Affiliation: | (Department of Clinical Laboratory,Jianhu County People′s Hospital,Yancheng, Jiangsu 224700,China;Department of Clinical Laboratory,Binhai County People′s Hospital,Yancheng,Jiangsu 224700,China;Department of Dermatology,Binhai County People′s Hospital,Yancheng,Jiangsu 224500,China) |
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| Abstract: | JU Feng;QIAN Lei;ZHENG Renshan;YU Jianxiu(Department of Clinical Laboratory,Jianhu County People′s Hospital,Yancheng, Jiangsu 224700,China;Department of Clinical Laboratory,Binhai County People′s Hospital,Yancheng,Jiangsu 224700,China;Department of Dermatology,Binhai County People′s Hospital,Yancheng,Jiangsu 224500,China) |
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| Keywords: | psoriasis metabolic syndrome lipoprotein-associated phospholipase A2 inflammatory factors |
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