| 胃癌组织HPV16、EB病毒及HBV感染的检测与分析 |
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| 引用本文： | 朱冠保,程骏,陈韶,张丽芳. 胃癌组织HPV16、EB病毒及HBV感染的检测与分析[J]. 温州医学院学报, 2002, 32(4): 215-216 |
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| 作者姓名： | 朱冠保 程骏 陈韶 张丽芳 |
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| 作者单位： | 1. 温州医学院第一附属医院普通外科,浙江,温州,325000
2. 温州医学院微生物学教研室,浙江,温州,325027 |
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| 基金项目： | 温州市科技发展基金资助项目 (S980 3 0 4B) |
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| 摘 要： | 目的：探讨肿瘤相关病毒HPV16、EB病毒及HBV感染与胃癌的相关性。方法：选择临床病理确诊的胃癌组织及其癌旁正常胃黏膜组织标本各40份，用PCR方法检测标本中HPV16、EB病毒及HBV DNA。结果：胃癌及癌旁正常胃黏膜组织标本中，HPV16DNA阳性检出率分别为25％（10／40）和0（0／40），EB病毒DNA阳性检出率分别为17．5％（7／40）和0（0／40），差异均有显性（P＜0．05）；HPV16、EB病毒DNA同时呈阳性的检出率为5％（2／40）；HBV DNA在胃癌组织和癌旁正常胃黏膜组织中的检出率均为0。结论：HPV16、EB病毒感染可能与胃癌的发生相关。
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| 关 键 词： | 胃癌 人乳头瘤病毒 EB病毒 乙肝病毒 相关性 PCR方法 |
| 文章编号： | 1000-2138(2002)04-0215-02 |
| 修稿时间： | 2002-01-07 |
Detection and Analysis of Human Papillomavirus 16, EBV and HBV Infection In Gastric Carcinoma |
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| ZHU Guan bao ,CHENG Jun,CHEN Shao,et al.. Detection and Analysis of Human Papillomavirus 16, EBV and HBV Infection In Gastric Carcinoma[J]. Journal of Wenzhou Medical College, 2002, 32(4): 215-216 |
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| Authors: | ZHU Guan bao CHENG Jun CHEN Shao et al. |
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| Affiliation: | ZHU Guan bao *,CHENG Jun,CHEN Shao,et al.* Department of Surgery,the First Affiliated Hospital,Wenzhou Medical College,Wenzhou 325000 |
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| Abstract: | Objective:To investigate the relationship between Human Papillomavirus (HPV) type 16, Epstein Barr Virus (EBV) and Hepatitis B virus (HBV) infections and gastric carcinoma (GC).Methods:Polymerase chain reaction (PCR) technique was used to detect HPV16, EBV and HBV DNA in 40 fresh GC and 40 fresh normal gastric mucosa adjacent to the tumour (NGMAT).Results:HPV16 DNA was found in 25% (10/40) of GC specimens and in none (0/40) of NGMAT (P<0.01), EBV DNA was found in 17.5% (7/40) of GC specimens and again in none (0/40) of NGMAT (P<0.01), HPV16 and EBV DNA was found in 5%(2/40) in GC specimens; HBV DNA was detected in none of GC specimens nor NGMAT.Conclusion:HPV16 and EBV infection are likely to be involved in the development of GC. |
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| Keywords: | gastric carcinoma human papillomavirus Epstein Barr virus hepatitis B virus |
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