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| 黄芩温度敏感凝胶剂的研究 | |
| 引用本文： | 宋成君,王莹,王春艳,田蕾,刘艳君,张瑞斌. 黄芩温度敏感凝胶剂的研究[J]. 中国中药杂志, 2008, 33(6): 628-631 |
| 作者姓名： | 宋成君 王莹 王春艳 田蕾 刘艳君 张瑞斌 |
| 作者单位： | 1. 哈尔滨瑞程阳光医药科技有限公司,黑龙江,哈尔滨,150025 2. 哈尔滨市第一医院,黑龙江,哈尔滨,150010 3. 沈阳药科大学,辽宁,沈阳,110016 |
| 摘 要： | 目的:研制黄芩温度敏感原位凝胶。方法:采用搅拌子法测定相转变温度并测定黏度,从而确定处方。测定了凝胶的眼刺激性。采用荧光示踪法观察了眼部滞留时间。结果:确定质量分数20%的泊洛沙姆407和10%的泊洛沙姆188作为黄芩温度敏感原位凝胶的基质。黄芩温度敏感原位凝胶对兔眼无刺激。凝胶的眼部滞留时间是(150±8)min。结论:黄芩温度敏感原位凝胶达到了滴入眼内形成凝胶并且延长滞留时间的目的。 |
| 关 键 词： | 黄芩 温度敏感 原位凝胶 泊洛沙姆 眼刺激性 眼部滞留时间 |
| 收稿时间： | 2007-05-30 |
Preparation and evaluation in vivo of scutellaria thermosensitive gel |
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| SONG Cheng-jun ;WANG Ying ;WANG Chun-yan ;TIAN Lei ;LIU Yan-jun ;ZHANG Rui-bin. Preparation and evaluation in vivo of scutellaria thermosensitive gel[J]. China Journal of Chinese Materia Medica, 2008, 33(6): 628-631 | |
| Authors: | SONG Cheng-jun WANG Ying WANG Chun-yan TIAN Lei LIU Yan-jun ZHANG Rui-bin |
| Affiliation: | Bright Way Pharmaceutical Technology limited company, Harbin 150025, China. dragonsongchj@163.com |
| Abstract: | Objective: To study scutellaria thermosensitive gel in situ.Method: The phase transition temperature of gel with various concentration polymer solutions was studied by using stirring method and the viscosity of gel was monitored under different temperatures.Eye irritation experiments were performed with rabbit.The duration of residence time in rabbit eyes of scutellaria thermosensitive gel was observed with 2% fluorescein.Result: 20% poloxmar407 and 10% poloxmar 188 were suitable to scutellaria thermosensitive gel in situ.The results suggested that the scutellaria thermosensitive gel in situ based on poloxmar were nonirritant and retention time on the surface of eye was(150±8) min.Conclusion: The scutellaria thermosensitive gel in situ forms gel in eye and has longer release time than that of eye drops. |
| Keywords: | scutellaria thermosensitive gel in situ poloxamer eye irritation residence time on ocular |
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