金芪降糖片改善2型糖尿病胰岛素抵抗的研究

目的：探讨金芪降糖片改善2型糖尿病胰岛素抵抗及胰高血糖素、生长抑素治疗前后变化。方法：2型糖尿病(T2DM)患者100例，辨证分为阴虚热盛、湿热困脾、气阴两虚和阴阳两虚4型，使用金芪降糖片，疗程3个月，治疗前后测定空腹血糖(FBG)、空腹胰岛素(FINS)、胰高血糖(Gluc)、生长抑素(SS)，并计算胰岛素敏感性(IAI)、胰岛素抵抗指数(HOMA—IR)。结果：金芪降糖片能降低。T2DM阴虚热盛型、湿热困脾型、气阴两虚型患者的Glue及升高ss，从而增加IAI，降低HOMA—IR，达到降低血糖。结论：金芪降糖片通过升高SS、降低Glue，改善2型糖尿病阴虚热盛型、湿热困脾型、气阴两虚型患者的胰岛素抵抗。

Study of Jinqi Melbine on Insulin Resistance in Type 2 Diabetes Mellitus

Objective: To investigate the change of insulin resistance(IR), Glucagon(Gluc), Somatostatin(SS) after using Jinqijiangtangpian(JQJTP). Methods: One hundred cases of T2DM were analyzed as 4 different types of ZHENG: the Yin-deficiency with excess of heat, the Dampness and heat in the spleen, the deficiency of Qi and Yin and the deficiency of Yin and Yang. Fasting blood glucose(FBG), fasting blood insulin(FINS), Gluc and SS were measured, and insulin sensitivity(IAI) and HOMA-IR were also calculated before and after the treatment of JQJTP in the course of 3 months. Results: JQJTP could increase SS and IAI while reducing Gluc and IR in the patients with the Yin-deficiency with excess of heat, the Dampness and heat in the spleen and the deficiency of Qi and Yin. Conclusion: JQJTP could improve the IR in the patients with the Yin-deficiency with excess of heat, the Dampness and heat in the spleen and the deficiency of Qi and Yin through increasing SS and reducing Gluc.