| 可溶性VEGF受体1在视网膜新生血管疾病中的研究进展 |
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| 引用本文： | 崔晓媛,徐国兴. 可溶性VEGF受体1在视网膜新生血管疾病中的研究进展[J]. 国际眼科杂志, 2018, 18(4): 649-651 |
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| 作者姓名： | 崔晓媛 徐国兴 |
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| 作者单位： | 中国福建省福州市,福建医科大学附属第一医院眼科 福建省眼科研究所,中国福建省福州市,福建医科大学附属第一医院眼科 福建省眼科研究所 |
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| 基金项目： | 福建省社会发展高校产学合作项目(No.2014Y4003) |
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| 摘 要： | 视网膜新生血管性疾病的共同特征是病理性新生血管形成。目前研究的内源性视网膜新生血管因子最主要的是VEGF。可溶性VEGF受体1(sFlt-1)是VEGFR-1的mRNA胞外区剪接形成的可溶性形式，只编码胞外区，缺乏细胞内酪氨酸激酶区域，所以其仅具有与配体结合的能力，而无信号转导能力，从而阻止新生血管的形成。sFlt-1作为近年来的研究热点，有可能成为治疗该类疾病的新的基因治疗方法。本文就sFlt-1在视网膜新生血管疾病治疗中的作用机制及研究进展做一综述。
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| 关 键 词： | 血管内皮生长因子 可溶性血管内皮生长因子受体1 视网膜新生血管 |
| 收稿时间： | 2017-08-24 |
| 修稿时间： | 2018-03-06 |
Research on soluble VEGF receptor 1 in retinal neovascularization |
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| Xiao-Yuan Cui and Guo-Xing Xu. Research on soluble VEGF receptor 1 in retinal neovascularization[J]. International Eye Science, 2018, 18(4): 649-651 |
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| Authors: | Xiao-Yuan Cui and Guo-Xing Xu |
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| Affiliation: | Fujian Institute of Ophthalmology; Department of Ophthalmology, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian Province, China and Fujian Institute of Ophthalmology; Department of Ophthalmology, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian Province, China |
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| Abstract: | The common feature of retinal neovascularization is the formation of pathological neovascularization. The primary one of endogenous retinal neovascularization factor in current research is vascular endothelial growth factor(VEGF). SFlt-1, the soluble form of splicing in mRNA extracellular region of VEGFR-1, which is short of intracellular tyrosine kinase domain can only encode the extracellular domain. Therefore, it only can bind with ligands but can not transmit signals, thus preventing the formation of neovascularization. SFlt-1, as a hot research topic in recent years, may provide a new gene therapy method for this disease. This review focus on the mechanism and research progress of sFlt-1 in retinal neovascularization. |
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| Keywords: | vascular endothelial growth factor soluble vascular endothelial growth factor receptor 1 retinal neovascularization |
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