Once-monthly administration of darbepoetin alfa for the treatment of patients with chronic heart failure and anemia: a pharmacokinetic and pharmacodynamic investigation |
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| Authors: | Cleland John G F Sullivan John T Ball Stephen Horowitz John D Agoram Balaji Rosser Dylan Yates Wayne Tin Lwin Fuentealba Paulina Burton Paul B J |
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| Affiliation: | Department of Cardiology, University of Hull, Castle Hill Hospital, Kingston upon Hull, UK. j.g.cleland@hull.ac.uk |
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| Abstract: | In patients with chronic heart failure (CHF), anemia is associated with more severe symptoms and worse prognosis. Erythropoiesis-stimulating proteins (ESPs) increase hemoglobin and may be of therapeutic benefit. We investigated the pharmacokinetics and pharmacodynamics of the long-acting ESP, darbepoetin alfa, administered on 2 occasions 1 month apart to 30 healthy subjects and 33 patients with symptomatic CHF and anemia (hemoglobin
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