| 乙酰肝素酶和基质金属蛋白酶-9在鼻咽癌组织中的表达及意义 |
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| 引用本文： | 吕春江,朱国臣,肖大江.乙酰肝素酶和基质金属蛋白酶-9在鼻咽癌组织中的表达及意义[J].中国耳鼻咽喉颅底外科杂志,2011(2):90-94. |
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| 作者姓名： | 吕春江 朱国臣 肖大江 |
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| 作者单位： | 南京医科大学附属无锡第二医院耳鼻咽喉科; |
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| 基金项目： | 无锡市科技局社会发展应用技术研究项目(项目编号:CSE01012); 南京医科大学科技发展基金面上项目(项目编号:07NMUM057) |
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| 摘 要： | 目的 探讨乙酰肝素酶(HPA)和基质金属蛋白酶-9(MMP-9)在鼻咽癌组织中的表达及意义.方法 采用免疫组化技术检测60例低分化鼻咽癌和20例鼻咽慢性炎症组织中HPA 和 MMP-9 的表达,并结合临床特征分析.结果 鼻咽慢性炎症组织中无HPA和MMP-9阳性表达.鼻咽癌组织中HPA和MMP-9阳性表达率分别为55....
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| 关 键 词： | 鼻咽肿瘤 乙酰肝素酶 基质金属蛋白酶 侵袭 转移 |
Expression of heparanase and matrix metalloproteinase-9 in nasopharyngeal carcinoma and its clinical significance |
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| LV Chun-jiang,ZHU Guo-chen,XIAO Da-jiang.Expression of heparanase and matrix metalloproteinase-9 in nasopharyngeal carcinoma and its clinical significance[J].Chinese Journal of Otorhinolaryngology-skull Base Surgery,2011(2):90-94. |
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| Authors: | LV Chun-jiang ZHU Guo-chen XIAO Da-jiang |
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| Institution: | LV Chun-jiang,ZHU Guo-chen,XIAO Da-jiang(Department of Otolaryngology,the Second People's Hospital of Wuxi,Affiliated to Nanjing Medical University,Wuxi 214002,China) |
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| Abstract: | Objective To investigate the expression of heparanase and matrix metalloproteinase-9(MMP-9) proteins as well as its clinical significance in nasopharyngeal carcinoma(NPC).Methods The expression of heparanase and MMP-9 proteins in 60 samples of poorly-differentiated NPC and 20 ones of chronic inflammatory tissue of nasopharynx was detected with immuno-histochemical staining separately.The results were analyzed in combination with the clinicopathological factors.Results The positive rates of heparanase and MM... |
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| Keywords: | Nasopharyngeal neoplasm Heparanase Matrix metalloproteinase-9 Invasive infiltration Metastasis |
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