| RECK和MMP-2在下咽癌中的表达及相关性研究 |
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| 引用本文： | 曾志梅,梁永辉,杨嶷芳,窦晓清,陈贤明. RECK和MMP-2在下咽癌中的表达及相关性研究[J]. 中国耳鼻咽喉颅底外科杂志, 2011, 0(2): 95-99 |
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| 作者姓名： | 曾志梅 梁永辉 杨嶷芳 窦晓清 陈贤明 |
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| 作者单位： | 南京军区福州总医院耳鼻咽喉头颈外科;福建医科大学福州总临床医学院; |
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| 摘 要： | 目的 探讨RECK与MMP-2蛋白表达与下咽癌侵润和转移的关系.方法 应用手术方法取下咽癌原发灶、癌旁组织及淋巴节转移组织22例,另取良性病变(声带息肉)10例作为对照,应用免疫组化检测RECK、MMP-2蛋白表达,并与下咽癌不同临床分期进行相关性分析.结果 RECK的表达水平在下咽癌原发灶、转移灶中均明显低于癌旁组...
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| 关 键 词： | 下咽肿瘤,癌 回复引导半胱氨酸丰富蛋白Kazal基元(RECK) 基质金属蛋白酶-2(MMP-2) 转移 |
Expression of RECK and matrix metalloprotease-2 in human carcinoma of hypopharynx and its relativity |
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| ZENG Zhi-mei,LIANG Yong-hui,YANG Yi-fang,et al.. Expression of RECK and matrix metalloprotease-2 in human carcinoma of hypopharynx and its relativity[J]. Chinese Journal of Otorhinolaryngology-skull Base Surgery, 2011, 0(2): 95-99 |
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| Authors: | ZENG Zhi-mei LIANG Yong-hui YANG Yi-fang et al. |
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| Affiliation: | ZENG Zhi-mei,LIANG Yong-hui,YANG Yi-fang,et al.(Department Of Otolaryngology-Head and Neck Surgery,Fuzhou General Hospita1 of PLA,Fuzhou 350025,China) |
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| Abstract: | Objective To study the expression of reversion inducing cysteine rich protein with Kazal motifs(RECK) and matrix metalloprotease-2(MMP-2) in hypopharyngeal carcinoma,and to explore the relationship between them.Methods The expression of RECK and MMP-2 was detected in specimens(including tumor tissue,metastatic lymph node and adjacent normal tissue) from 22 cases with hypopharynx carcinoma and 10 specimens of benign lession(vocal polyp) with immumohistochemistry.The tumor tissue,metastatic lymph node and adj... |
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| Keywords: | Hypopharyngeal neoplasm carcinoma RECK MMP-2 Metastasis |
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