| 胃癌化疗前后循环血浆VEGF、IL-8变化的临床意义 |
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| 引用本文： | 王友春,马建党,韩宏锋,陈宏伟,范银忠.胃癌化疗前后循环血浆VEGF、IL-8变化的临床意义[J].胃肠病学和肝病学杂志,2008,17(3):226-227. |
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| 作者姓名： | 王友春 马建党 韩宏锋 陈宏伟 范银忠 |
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| 作者单位： | 1. 河南省洛阳市中心医院消化内科,河南,洛阳,471009
2. 河南省洛阳市中心医院检验科,河南,洛阳,471009 |
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| 摘 要： | 目的探讨VEGF、IL-8在胃癌患者化疗前后血浆中表达的临床意义。方法采用酶联免疫吸附法（ELISA）分别检测45例胃癌患者化疗前后血浆VEGF、IL-8水平，10名正常健康志愿者血浆作为对照。结果恶性肿瘤组化疗前血浆VEGF、IL-8含量明显高于对照组（P〈0．001），与TNM分期有关，但与肿瘤组织分化类型无明显相关性。化疗后血浆VEGF、IL-8显著下降（P〈0.001）。结论VEGF、IL-8是肿瘤发展和转移的有效生物学指标。化疗后VEGF、IL-8的表达量可能有助于临床判断化疗近期疗效。
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| 关 键 词： | 胃癌 VEGF IL-8 ELISA 化疗 |
| 文章编号： | 1006-5709(2008)03-0226-02 |
| 修稿时间： | 2007年11月6日 |
Expressions of plasma VEGF, IL-8 before and after chemotherapy in gastric cancer patients |
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| WANG Youchun,MA Jiandang,HAN Hongfeng,CHEN hongwei,FAN Yinzhong.Expressions of plasma VEGF, IL-8 before and after chemotherapy in gastric cancer patients[J].Chinese Journal of Gastroenterology and Hepatology,2008,17(3):226-227. |
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| Authors: | WANG Youchun MA Jiandang HAN Hongfeng CHEN hongwei FAN Yinzhong |
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| Institution: | WANG Youchun , MA Jiandang, HAN Hongfeng , CHEN hongwei , FAN Yinzhong(1.Department of Gastroenterology; 2.Department of Clinical Laboratory, the Central Hospital of Luoyang, Luoyang 471009, China) |
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| Abstract: | Objective To investigate the clinical significance of expressions of plasma VEGF, IL-8 before and after chemotherapy in gastric cancer patients. Methods The plasma VEGF, IL-8 were measured in 45 gastric cancer patients before and after chemotherapy. Meanwhile, 10 healthy volunteers were involved in the control. Results VEGF, IL-8 plasma levels before chemotherapy were found significantly higher in cancer patients than that in the controls （P 〈 0. 001 ）. Moreover, they were significantly increased in stage N patients compared with that in the stage Ⅱ and stage Ⅲ patients. But there was no relationship with differentiation. VEGF, IL-8 plasma levels were decreased significantly after chemotherapy （P 〈 O. 001 ）. Conclusion VEGF, IL-8 are useful biological marks in finding out recurrence and metastasis. The levels of VEGF, IL-8 after chemotherapy may reflect the therapeutic effect. |
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| Keywords: | Gastric cancer VEGF IL-8 ELISA Chemotherapy |
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